Search or filter publications

Search publications Search

Filter by type:

Filter by publication type

• Book
• Book chapter
• Conference paper
• Journal article
• Patent
• Report
• Software

Filter by year:

Filter from 2022202120202019201820172016201520142013 to Filter to 2022202120202019201820172016201520142013

---

Search results

• Journal article
  Zheng W, Pena A, Low WW, Wong JLC, Frankel G, Egelman EHet al., 2020,

  Cryoelectron-Microscopic Structure of the pKpQIL Conjugative Pili from Carbapenem-Resistant Klebsiella pneumoniae

  , STRUCTURE, Vol: 28, Pages: 1321-+, ISSN: 0969-2126
  • Author Web Link
  • Cite
  • Citations: 8
• Journal article
  Zhyvoloup A, Yu BYK, Bakovic J, Davis-Lunn M, Tossounian M-A, Thomas N, Tsuchiya Y, Peak-Chew SY, Wigneshweraraj S, Filonenko V, Skehel M, Setlow P, Gout Iet al., 2020,

  Analysis of disulphide bond linkage between CoA and protein cysteine thiols during sporulation and in spores of Bacillus species

  , FEMS MICROBIOLOGY LETTERS, Vol: 367, ISSN: 0378-1097
  • Author Web Link
  • Cite
  • Citations: 3
• Journal article
  Pagani N, Armstrong-James D, Reed A, 2020,

  Successful salvage therapy for fungal bronchial anastomotic infection after-lung transplantation with an inhaled triazole anti-fungal PC945

  , JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol: 39, Pages: 1505-1506, ISSN: 1053-2498
  • Author Web Link
  • Cite
  • Citations: 5
• Journal article
  Williams TJ, Harvey S, Armstrong-James D, 2020,

  Immunotherapeutic approaches for fungal infections

  , CURRENT OPINION IN MICROBIOLOGY, Vol: 58, Pages: 130-137, ISSN: 1369-5274
  • Author Web Link
  • Cite
  • Citations: 6
• Journal article
  Singanayagam A, Johnston SL, 2020,

  Long-term impact of inhaled corticosteroid use in asthma and chronic obstructive pulmonary disease (COPD): Review of mechanisms that underlie risks

  , JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 146, Pages: 1292-1294, ISSN: 0091-6749
  • Author Web Link
  • Cite
  • Citations: 11
• Journal article
  Zhong Q, Roumeliotis T, Kozik Z, Cepeda-Molero M, Angel Fernandez L, Shenoy AR, Bakal C, Frankel G, Choudhary JSet al., 2020,

  Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx-dependent pyroptosis in intestinal epithelial cells

  , PLoS Biology, Vol: 18, ISSN: 1544-9173

  Clustering of the enteropathogenic Escherichia coli (EPEC) type III secretion system (T3SS) effector translocated intimin receptor (Tir) by intimin leads to actin polymerisation and pyroptotic cell death in macrophages. The effect of Tir clustering on the viability of EPEC-infected intestinal epithelial cells (IECs) is unknown. We show that EPEC induces pyroptosis in IECs in a Tir-dependent but actin polymerisation-independent manner, which was enhanced by priming with interferon gamma (IFNγ). Mechanistically, Tir clustering triggers rapid Ca2+ influx, which induces lipopolysaccharide (LPS) internalisation, followed by activation of caspase-4 and pyroptosis. Knockdown of caspase-4 or gasdermin D (GSDMD), translocation of NleF, which blocks caspase-4 or chelation of extracellular Ca2+, inhibited EPEC-induced cell death. IEC lines with low endogenous abundance of GSDMD were resistant to Tir-induced cell death. Conversely, ATP-induced extracellular Ca2+ influx enhanced cell death, which confirmed the key regulatory role of Ca2+ in EPEC-induced pyroptosis. We reveal a novel mechanism through which infection with an extracellular pathogen leads to pyroptosis in IECs.

  • Abstract
  • Author Web Link
  • Open Access Link
  • Cite
• Journal article
  Frosini SM, Bond R, McCarthy AJ, Feudi C, Schwarz S, Lindsay JA, Loeffler Aet al., 2020,

  Genes on the Move: In Vitro Transduction of Antimicrobial Resistance Genes between Human and Canine Staphylococcal Pathogens

  , MICROORGANISMS, Vol: 8
  • Author Web Link
  • Cite
  • Citations: 5
• Journal article
  Murray A, Cass L, Ito K, Pagani N, Armstrong-James D, Dalal P, Reed A, Strong Pet al., 2020,

  PC945, a Novel Inhaled Antifungal Agent, for the Treatment of Respiratory Fungal Infections

  , JOURNAL OF FUNGI, Vol: 6
  • Author Web Link
  • Cite
  • Citations: 6
• Journal article
  Farne H, Singanayagam A, 2020,

  Why asthma might surprisingly protect against poor outcomes in COVID-19

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 56, ISSN: 0903-1936
  • Author Web Link
  • Cite
  • Citations: 17
• Journal article
  Ovadia C, Perdones-Montero A, Fan HM, Mullish BH, McDonald JAK, Papacleovoulou G, Wahlström A, Ståhlman M, Tsakmaki A, Clarke LCD, Sklavounos A, Dixon PH, Bewick GA, Walters JRF, Marschall H-U, Marchesi JR, Williamson Cet al., 2020,

  Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy

  , Scientific Reports, Vol: 10

  <jats:title>Abstract</jats:title><jats:p>Ursodeoxycholic acid (UDCA) treatment can reduce itch and lower endogenous serum bile acids in intrahepatic cholestasis of pregnancy (ICP). We sought to determine how it could influence the gut environment in ICP to alter enterohepatic signalling. The gut microbiota and bile acid content were determined in faeces from 35 pregnant women (14 with uncomplicated pregnancies and 21 with ICP, 17 receiving UDCA). Faecal bile salt hydrolase activity was measured using a precipitation assay. Serum fibroblast growth factor 19 (FGF19) and 7α-hydroxy-4-cholesten-3-one (C4) concentrations were measured following a standardised diet for 21 hours. Women with a high ratio of <jats:italic>Bacteroidetes</jats:italic> to <jats:italic>Firmicutes</jats:italic> were more likely to be treated with UDCA (Fisher’s exact test p = 0.0178) than those with a lower ratio. Bile salt hydrolase activity was reduced in women with low <jats:italic>Bacteroidetes</jats:italic>:<jats:italic>Firmicutes</jats:italic>. Women taking UDCA had higher faecal lithocholic acid (p &lt; 0.0001), with more unconjugated bile acids than women with untreated ICP or uncomplicated pregnancy. UDCA-treatment increased serum FGF19, and reduced C4 (reflecting lower bile acid synthesis). During ICP, UDCA treatment can be associated with enrichment of the gut microbiota with <jats:italic>Bacteroidetes</jats:italic>. These demonstrate high bile salt hydrolase activity, which deconjugates bile acids enabling secondary modification to FXR agonists, enhancing enterohepatic feedback via FGF19.</jats:p>

  • Abstract
  • Open Access Link
  • Cite

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.