Search or filter publications

Search publications Search

Filter by type:

Filter by publication type

• Book
• Book chapter
• Conference paper
• Journal article
• Patent
• Report
• Software

Filter by year:

Filter from 2022202120202019201820172016201520142013 to Filter to 2022202120202019201820172016201520142013

---

Search results

• Journal article
  Eldridge MJG, Shenoy AR, 2015,

  Antimicrobial inflammasomes: unified signalling against diverse bacterial pathogens

  , CURRENT OPINION IN MICROBIOLOGY, Vol: 23, Pages: 32-41, ISSN: 1369-5274
  • Author Web Link
  • Cite
  • Citations: 29
• Journal article
  Campeotto I, Zhang Y, Mladenov MG, Freemont PS, Grundling Aet al., 2015,

  Complex Structure and Biochemical Characterization of the Staphylococcus aureus Cyclic Diadenylate Monophosphate (c-di-AMP)-binding Protein PstA, the Founding Member of a New Signal Transduction Protein Family

  , Journal of Biological Chemistry, Vol: 290, Pages: 2888-2901, ISSN: 1083-351X

  Signaling nucleotides are integral parts of signal transductionsystems allowing bacteria to cope with and rapidly respond tochanges in the environment. The Staphylococcus aureus PII-likesignal transduction protein PstA was recently identified as acyclic diadenylate monophosphate (c-di-AMP)-binding protein.Here, we present the crystal structures of the apo- and c-diAMP-boundPstA protein, which is trimeric in solution as wellas in the crystals. The structures combined with detailed bioinformaticsanalysis revealed that the protein belongs to a newfamily of proteins with a similar core fold but with distinct featuresto classical PII proteins, which usually function in nitrogenmetabolism pathways in bacteria. The complex structurerevealed three identical c-di-AMP-binding sites per trimer witheach binding site at a monomer-monomer interface. Althoughdistinctly different from other cyclic-di-nucleotide-bindingsites, as the half-binding sites are not symmetrical, the complexstructure also highlighted common features for c-di-AMPbindingsites. A comparison between the apo and complexstructures revealed a series of conformational changes thatresult in the ordering of two anti-parallel !-strands that protrudefrom each monomer and allowed us to propose a mechanismon how the PstA protein functions as a signaling transductionprotein.

  • Abstract
  • Open Access Link
  • Cite
• Journal article
  Schreiber F, Kay S, Frankel G, Clare S, Goulding D, van de Vosse E, van Dissel JT, Strugnell R, Thwaites G, Kingsley RA, Dougan G, Baker Set al., 2015,

  The Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions

  , SCIENTIFIC REPORTS, Vol: 5, ISSN: 2045-2322
  • Author Web Link
  • Open Access Link
  • Cite
  • Citations: 10
• Journal article
  Huynh M-H, Liu B, Henry M, Liew L, Matthews SJ, Carruthers VBet al., 2015,

  Structural Basis of Toxoplasma gondii MIC2-associated Protein Interaction with MIC2

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 290, Pages: 1432-1441
  • Author Web Link
  • Open Access Link
  • Cite
  • Citations: 15
• Journal article
  Woodcock KJ, Kierdorf K, Pouchelon CA, Vivancos V, Dionne MS, Geissmann Fet al., 2015,

  Macrophage-derived upd3 Cytokine causes impaired glucose homeostasis and reduced lifespan in drosophila fed a lipid-rich diet

  , Immunity, Vol: 42, Pages: 133-144, ISSN: 1097-4180

  Long-term consumption of fatty foods is associated with obesity, macrophage activation and inflammation, metabolic imbalance, and a reduced lifespan. We took advantage of Drosophila genetics to investigate the role of macrophages and the pathway(s) that govern their response to dietary stress. Flies fed a lipid-rich diet presented with increased fat storage, systemic activation of JAK-STAT signaling, reduced insulin sensitivity, hyperglycemia, and a shorter lifespan. Drosophila macrophages produced the JAK-STAT-activating cytokine upd3, in a scavenger-receptor (crq) and JNK-dependent manner. Genetic depletion of macrophages or macrophage-specific silencing of upd3 decreased JAK-STAT activation and rescued insulin sensitivity and the lifespan of Drosophila, but did not decrease fat storage. NF-κB signaling made no contribution to the phenotype observed. These results identify an evolutionarily conserved “scavenger receptor-JNK-type 1 cytokine” cassette in macrophages, which controls glucose metabolism and reduces lifespan in Drosophila maintained on a lipid-rich diet via activation of the JAK-STAT pathway.

  • Abstract
  • Publisher Web Link
  • Open Access Link
  • Cite
• Journal article
  McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic Iet al., 2015,

  PLEKHM1 Regulates Salmonella-Containing Vacuole Biogenesis and Infection

  , CELL HOST & MICROBE, Vol: 17, Pages: 58-71, ISSN: 1931-3128
  • Author Web Link
  • Cite
  • Citations: 61
• Journal article
  Holden DW, 2015,

  Persisters unmasked

  , SCIENCE, Vol: 347, Pages: 30-32, ISSN: 0036-8075
  • Author Web Link
  • Cite
  • Citations: 23
• Journal article
  Larrouy-Maumus G, Puzo G, 2015,

  Mycobacterial envelope lipids fingerprint from direct MALDI-TOF MS analysis of intact bacilli

  , TUBERCULOSIS, Vol: 95, Pages: 75-85, ISSN: 1472-9792
  • Author Web Link
  • Cite
  • Citations: 18
• Journal article
  Filloux A, 2015,

  Untitled

  , FEMS MICROBIOLOGY REVIEWS, Vol: 39, Pages: 1-1, ISSN: 0168-6445
  • Author Web Link
  • Cite
• Book chapter
  Thurston TLM, holden DW, 2015,

  interactions between salmonella and the autophagy system

  , Autophagy, infection, and the immune response, Editors: jackson, swanson, Publisher: Wiley Blackwell, ISBN: 978-1-118-67764-3
  • Cite

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.