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• Journal article
  Mousnier A, Schroeder GN, Stoneham CA, So EC, Garnett JA, Yu L, Matthews SJ, Choudhary JS, Hartland EL, Frankel Get al., 2014,

  A New Method To Determine In Vivo Interactomes Reveals Binding of the Legionella pneumophila Effector PieE to Multiple Rab GTPases

  , MBIO, Vol: 5, ISSN: 2150-7511
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  • Citations: 27
• Journal article
  Domingues L, Holden DW, Mota LJ, 2014,

  The Salmonella Effector SteA Contributes to the Control of Membrane Dynamics of Salmonella-Containing Vacuoles

  , INFECTION AND IMMUNITY, Vol: 82, Pages: 2923-2934, ISSN: 0019-9567
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  • Citations: 28
• Journal article
  Lin J, Oh S-H, Jones R, Garnett JA, Salgado PS, Rusnakova S, Matthews SJ, Hoyer LL, Cota Eet al., 2014,

  The peptide-binding cavity Is essential for Als3-mediated adhesion of Candida albicans to human cells

  , Journal of Biological Chemistry, Vol: 289, Pages: 18401-18412, ISSN: 1083-351X

  Background: Of the eight cell surface glycoproteins in the C. albicans Als family, Als3 makes the largest contribution to adhesion to human cells.Results: Mutation of the Als3 peptide-binding cavity (PBC) results in loss of Als3 adhesive function.Conclusion: The PBC is required for Als3 adhesive function.Significance: Interfering with PBC function is a viable strategy for inhibiting C. albicans adhesion.

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• Journal article
  Ma L-S, Hachani A, Lin J-S, Filloux A, Lai E-Met al., 2014,

  Agrobacterium tumefaciens Deploys a Superfamily of Type VI Secretion DNase Effectors as Weapons for Interbacterial Competition In Planta

  , Cell Host & Microbe, Vol: 16, Pages: 94-104, ISSN: 1934-6069

  The type VI secretion system (T6SS) is a widespread molecular weapon deployed by many Proteobacteria to target effectors/toxins into both eukaryotic and prokaryotic cells. We report that Agrobacterium tumefaciens, a soil bacterium that triggers tumorigenesis in plants, produces a family of type VI DNase effectors (Tde) that are distinct from previously known polymorphic toxins and nucleases. Tde exhibits an antibacterial DNase activity that relies on a conserved HxxD motif and can be counteracted by a cognate immunity protein, Tdi. In vitro, A. tumefaciens T6SS could kill Escherichia coli but triggered a lethal counterattack by Pseudomonas aeruginosa upon injection of the Tde toxins. However, in an in planta coinfection assay, A. tumefaciens used Tde effectors to attack both siblings cells and P. aeruginosa to ultimately gain a competitive advantage. Such acquired T6SS-dependent fitness in vivo and conservation of Tde-Tdi couples in bacteria highlights a widespread antibacterial weapon beneficial for niche colonization.

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• Journal article
  Esmail H, Barry CE, Young DB, Wilkinson RJet al., 2014,

  The ongoing challenge of latent tuberculosis

  , PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 369, ISSN: 0962-8436
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  • Citations: 181
• Journal article
  Xu Y, Plechanovova A, Simpson P, Marchant J, Leidecker O, Kraatz S, Hay RT, Matthews SJet al., 2014,

  Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4

  , NATURE COMMUNICATIONS, Vol: 5, ISSN: 2041-1723
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  • Citations: 45
• Journal article
  Lambert SM, Langley DR, Garnett JA, Angell R, Hedgethorne K, Meanwell NA, Matthews SJet al., 2014,

  The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors

  , PROTEIN SCIENCE, Vol: 23, Pages: 723-734, ISSN: 0961-8368
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  • Citations: 75
• Journal article
  Brown DR, Barton G, Pan Z, Buck M, Wigneshweraraj Set al., 2014,

  Nitrogen stress response and stringent response are coupled in Escherichia coli

  , Nature Communications, Vol: 5, ISSN: 2041-1723

  Assimilation of nitrogen is an essential process in bacteria. The nitrogen regulation stress response is an adaptive mechanism used by nitrogen-starved Escherichia coli to scavenge for alternative nitrogen sources and requires the global transcriptional regulator NtrC. In addition, nitrogen-starved E. coli cells synthesize a signal molecule, guanosine tetraphosphate (ppGpp), which serves as an effector molecule of many processes including transcription to initiate global physiological changes, collectively termed the stringent response. The regulatory mechanisms leading to elevated ppGpp levels during nutritional stresses remain elusive. Here, we show that transcription of relA, a key gene responsible for the synthesis of ppGpp, is activated by NtrC during nitrogen starvation. The results reveal that NtrC couples these two major bacterial stress responses to manage conditions of nitrogen limitation, and provide novel mechanistic insights into how a specific nutritional stress leads to elevating ppGpp levels in bacteria.

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• Journal article
  Phetcharaburanin J, Hong HA, Colenutt C, Bianconi I, Sempere L, Permpoonpattana P, Smith K, Dembek M, Tan S, Brisson M-C, Brisson AR, Fairweather NF, Cutting SMet al., 2014,

  The spore-associated protein BclA1 affects the susceptibility of animals to colonization and infection by Clostridium difficile

  , MOLECULAR MICROBIOLOGY, Vol: 92, Pages: 1025-1038, ISSN: 0950-382X
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  • Citations: 32
• Journal article
  Prosser GA, Larrouy-Maumus G, de Carvalho LPS, 2014,

  Metabolomic strategies for the identification of new enzyme functions and metabolic pathways

  , EMBO REPORTS, Vol: 15, Pages: 657-669, ISSN: 1469-221X
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  • Citations: 71

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