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• Journal article
  Gouzy A, Larrouy-Maumus G, Wu T-D, Peixoto A, Levillain F, Lugo-Villarino G, Guerquin-Kern J-L, de Carvalho LPS, Poquet Y, Neyrolles Oet al., 2013,

  Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate

  , NATURE CHEMICAL BIOLOGY, Vol: 9, Pages: 674-+, ISSN: 1552-4450
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  • Citations: 71
• Journal article
  Lu Z, Bergeron JRC, Atkinson RA, Schaller T, Veselkov DA, Oregioni A, Yang Y, Matthews SJ, Malim MH, Sanderson MRet al., 2013,

  Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction

  , Open Biology, Vol: 3, Pages: 1-11, ISSN: 2046-2441

  The HIV-1 viral infectivity factor (Vif) neutralizes cell-encoded antiviral APOBEC3 proteins by recruiting a cellular ElonginB (EloB)/ElonginC (EloC)/Cullin5-containing ubiquitin ligase complex, resulting in APOBEC3 ubiquitination and proteolysis. The suppressors-of-cytokine-signalling-like domain (SOCS-box) of HIV-1 Vif is essential for E3 ligase engagement, and contains a BC box as well as an unusual proline-rich motif. Here, we report the NMR solution structure of the Vif SOCS–ElonginBC (EloBC) complex. In contrast to SOCS-boxes described in other proteins, the HIV-1 Vif SOCS-box contains only one α-helical domain followed by a β-sheet fold. The SOCS-box of Vif binds primarily to EloC by hydrophobic interactions. The functionally essential proline-rich motif mediates a direct but weak interaction with residues 101–104 of EloB, inducing a conformational change from an unstructured state to a structured state. The structure of the complex and biophysical studies provide detailed insight into the function of Vif's proline-rich motif and reveal novel dynamic information on the Vif–EloBC interaction.

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• Journal article
  Lai Y, Rosenshine I, Leong JM, Frankel Get al., 2013,

  Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli

  , CELLULAR MICROBIOLOGY, Vol: 15, Pages: 1796-1808, ISSN: 1462-5814
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  • Citations: 75
• Journal article
  Mercedes Palomino M, Allievi MC, Gruendling A, Sanchez-Rivas C, Ruzal SMet al., 2013,

  Osmotic stress adaptation in Lactobacillus casei BL23 leads to structural changes in the cell wall polymer lipoteichoic acid

  , MICROBIOLOGY-SGM, Vol: 159, Pages: 2416-2426, ISSN: 1350-0872
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  • Citations: 28
• Journal article
  Harding CR, Mattheis C, Mousnier A, Oates CV, Hartland EL, Frankel G, Schroeder GNet al., 2013,

  LtpD Is a Novel Legionella pneumophila Effector That Binds Phosphatidylinositol 3-Phosphate and Inositol Monophosphatase IMPA1

  , INFECTION AND IMMUNITY, Vol: 81, Pages: 4261-4270, ISSN: 0019-9567
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  • Citations: 26
• Journal article
  Clark RI, Tan SWS, Pean CB, Roostalu U, Vivancos V, Bronda K, Pilatova M, Fu J, Walker DW, Berdeaux R, Geissmann F, Dionne MSet al., 2013,

  MEF2 Is an In Vivo Immune-Metabolic Switch

  , CELL, Vol: 155, Pages: 435-447, ISSN: 0092-8674
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  • Citations: 99
• Journal article
  Dionne MS, 2013,

  Comparative immunology: allorecognition and variable surface receptors outside the jawed vertebrates

  , CURRENT OPINION IN IMMUNOLOGY, Vol: 25, Pages: 608-612, ISSN: 0952-7915
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  • Citations: 3
• Journal article
  Tulli L, Marchi S, Petracca R, Shaw HA, Fairweather NF, Scarselli M, Soriani M, Leuzzi Ret al., 2013,

  CbpA: a novel surface exposed adhesin of Clostridium difficile targeting human collagen

  , CELLULAR MICROBIOLOGY, Vol: 15, Pages: 1674-1687, ISSN: 1462-5814
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  • Citations: 39
• Journal article
  Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Lung TWF, Mansell A, Riedmaier P, Oates CVL, Zaid A, Muehlen S, Crepin VF, Marches O, Ang C-S, Williamson NA, O'Reilly LA, Bankovacki A, Nachbur U, Infusini G, Webb AI, Silke J, Strasser A, Frankel G, Hartland ELet al., 2013,

  A type III effector antagonizes death receptor signalling during bacterial gut infection

  , NATURE, Vol: 501, Pages: 247-+, ISSN: 0028-0836
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  • Citations: 194
• Journal article
  Reichmann NT, Cassona CP, Gruendling A, 2013,

  Revised mechanism of D-alanine incorporation into cell wall polymers in Gram-positive bacteria

  , MICROBIOLOGY-SGM, Vol: 159, Pages: 1868-1877, ISSN: 1350-0872
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  • Citations: 66

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