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  • Journal article
    Permpoonpattana P, Phetcharaburanin J, Mikelsone A, Dembek M, Tan S, Brisson M-C, La Ragione R, Brisson AR, Fairweather N, Hong HA, Cutting SMet al., 2013,

    Functional Characterization of Clostridium difficile Spore Coat Proteins

    , JOURNAL OF BACTERIOLOGY, Vol: 195, Pages: 1492-1503, ISSN: 0021-9193
  • Journal article
    Hachani A, Lossi NS, Filloux A, 2013,

    A visual assay to monitor T6SS-mediated bacterial competition

    , Jove-Journal of Visualized Experiments, ISSN: 1940-087X

    Type VI secretion systems (T6SSs) are molecular nanomachines allowing Gram-negative bacteria to transport and inject proteins into a wide variety of target cells1,2. The T6SS is composed of 13 core components and displays structural similarities with the tail-tube of bacteriophages3. The phage uses a tube and a puncturing device to penetrate the cell envelope of target bacteria and inject DNA. It is proposed that the T6SS is an inverted bacteriophage device creating a specific path in the bacterial cell envelope to drive effectors and toxins to the surface. The process could be taken further and the T6SS device could perforate other cells with which the bacterium is in contact, thus injecting the effectors into these targets. The tail tube and puncturing device parts of the T6SS are made with Hcp and VgrG proteins, respectively4,5.The versatility of the T6SS has been demonstrated through studies using various bacterial pathogens. The Vibrio cholerae T6SS can remodel the cytoskeleton of eukaryotic host cells by injecting an "evolved" VgrG carrying a C-terminal actin cross-linking domain6,7. Another striking example was recently documented using Pseudomonas aeruginosa which is able to target and kill bacteria in a T6SS-dependent manner, therefore promoting the establishment of bacteria in specific microbial niches and competitive environment8,9,10.In the latter case, three T6SS-secreted proteins, namely Tse1, Tse2 and Tse3 have been identified as the toxins injected in the target bacteria (Figure 1). The donor cell is protected from the deleterious effect of these effectors via an anti-toxin mechanism, mediated by the Tsi1, Tsi2 and Tsi3 immunity proteins8,9,10. This antimicrobial activity can be monitored when T6SS-proficient bacteria are co-cultivated on solid surfaces in competition with other bacterial species or with T6SS-inactive bacteria of the same species8,11,12,13.The data available emphasized a numerical approach to the bacterial competition assay
  • Journal article
    Clare S, John V, Walker AW, Hill JL, Abreu-Goodger C, Hale C, Goulding D, Lawley TD, Mastroeni P, Frankel G, Enright AJ, Vigorito E, Dougan Get al., 2013,

    Enhanced Susceptibility to Citrobacter rodentium Infection in MicroRNA-155-Deficient Mice

    , INFECTION AND IMMUNITY, Vol: 81, Pages: 723-732, ISSN: 0019-9567
  • Journal article
    Firdessa R, Berg S, Hailu E, Schelling E, Gumi B, Erenso G, Gadisa E, Kiros T, Habtamu M, Hussein J, Zinsstag J, Robertson BD, Ameni G, Lohan AJ, Loftus B, Comas I, Gagneux S, Tschopp R, Yamuah L, Hewinson G, Gordon SV, Young DB, Aseffa Aet al., 2013,

    Mycobacterial Lineages Causing Pulmonary and Extrapulmonary Tuberculosis, Ethiopia

    , Emerging Infectious Diseases, Vol: 19, Pages: 460-463, ISSN: 1080-6059

    Molecular typing of 964 specimens from patients in Ethiopia with lymph node or pulmonary tuberculosis showed a similar distribution of Mycobacterium tuberculosis strains between the 2 disease manifestations and a minimal role for M. bovis. We report a novel phylogenetic lineage of M. tuberculosis strongly associated with the Horn of Africa.
  • Journal article
    Williams KJ, Bennett MH, Barton GR, Jenkins VA, Robertson BDet al., 2013,

    Adenylylation of mycobacterial Glnk (PII) protein is induced by nitrogen limitation

    , TUBERCULOSIS, Vol: 93, Pages: 198-206, ISSN: 1472-9792
  • Journal article
    Shadrin A, Sheppard C, Savalia D, Severinov K, Wigneshweraraj Set al., 2013,

    Overexpression of Escherichia coli udk mimics the absence of T7 Gp2 function and thereby abrogates successful infection by T7 phage

    , MICROBIOLOGY-SGM, Vol: 159, Pages: 269-274, ISSN: 1350-0872
  • Journal article
    Mesquita FS, Holden DW, Rolhion N, 2013,

    Lack of Effect of the Salmonella Deubiquitinase SseL on the NF-kappa B Pathway

    , PLOS ONE, Vol: 8, ISSN: 1932-6203
  • Journal article
    Lew JM, Mao C, Shukla M, Warren A, Will R, Kuznetsov D, Xenarios I, Robertson BD, Gordon SV, Schnappinger D, Cole ST, Sobral Bet al., 2013,

    Database resources for the tuberculosis community

    , TUBERCULOSIS, Vol: 93, Pages: 12-17, ISSN: 1472-9792
  • Book chapter
    Clements A, Berger CN, Lomma M, Frankel Get al., 2013,

    Type 3 secretion effectors

    , Escherichia coliPathotypes and Principles of Pathogenesis, Editors: Donnenberg, ISBN: 978-0-12-397048-0
  • Patent
    ,

    Anti-bacterial methods & materials

    , WO99/01473

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