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• Journal article
  Corcoles EP, Deeb S, Hanna G, Boutelle MG, Darzi Aet al., 2011,

  Adaptation of on-line rapid sampling microdialysis to monitor human intestinal ischaemia

  , Jurnal Teknologi (Sciences and Engineering), Vol: 54, Pages: 47-59, ISSN: 0127-9696

  Intestinal ischaemia or poor perfusion of the gastrointestinal tract is a major cause of post-operative mortality in abdominal surgery. Currently diagnosis of ischaemia relies only on clinical symptoms. Thus, monitoring bowel metabolism as an early marker of intestinal ischaemia is necessary. Human bowel microdialysis has been used in the past to study the metabolism of ichaemia collecting dialysate samples from the peritoneal cavity every 60 minutes. These sampling times carry a long delay for the detection of the typically rapid ischaemic event. We have previously developed a successful biosensor system to monitor neurochemicals in the human brain during surgery and in the intensive care unit The method consists of a flow injection analysis (FIA) system coupled to an enzyme based amperometric detector. The rapid sampling microdialysis monitoring system analysed electrochemically the dialysate glucose and lactate at high time resolution (typically 30 second sampling). Adaptation of the analytical assay system for on-line microdialysis monitoring of human bowel was performed and validated for in vivo procedures. Optimum membranes loading ratios were found to be 1:0.5 GOx:HRP and 2:0.5 LOx:HRP. The ischemic range was found to be 15μM-400μM, 40μM-6mM for glucose and lactate, respectively. The calibration method for these monitorings was concluded with a range from 250 μM to 6 mM. © Universiti Teknologi Malaysia.

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• Journal article
  Rogers M, Leong C, Niu X, de Mello A, Parker KH, Boutelle MGet al., 2011,

  Optimisation of a microfluidic analysis chamber for the placement of microelectrodes

  , PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 13, Pages: 5298-5303, ISSN: 1463-9076
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  • Citations: 21
• Journal article
  Feuerstein D, Manning A, Hashemi P, Bhatia R, Fabricius M, Tolias C, Pahl C, Ervine M, Strong AJ, Boutelle MGet al., 2010,

  Dynamic metabolic response to multiple spreading depolarizations in patients with acute brain injury: an online microdialysis study

  , JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 30, Pages: 1343-1355, ISSN: 0271-678X
  • Author Web Link
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  • Citations: 92
• Journal article
  Feuerstein D, Parker KH, Boutelle MG, 2009,

  Practical Methods for Noise Removal: Applications to Spikes, Nonstationary Quasi-Periodic Noise, and Baseline Drift

  , ANALYTICAL CHEMISTRY, Vol: 81, Pages: 4987-4994, ISSN: 0003-2700
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  • Citations: 49
• Journal article
  Hashemi P, Bhatia R, Nakamura H, Dreier JP, Graf R, Strong AJ, Boutelle MGet al., 2009,

  Persisting depletion of brain glucose following cortical spreading depression, despite apparent hyperaemia: evidence for risk of an adverse effect of Leao's spreading depression

  , JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 29, Pages: 166-175, ISSN: 0271-678X
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  • Citations: 79
• Conference paper
  Feuerstein D, Manning A, Hashemi P, Fabricius M, Strong AJ, Boutelle MGet al., 2009,

  Local dynamic metabolic response to spontaneous spreading depolarisations in the penumbra of the acutely injured human brain

  , Brain 09, Publisher: Nature Publishing, Pages: S57-S57, ISSN: 0271-678X
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• Journal article
  Deeba S, Corcoles EP, Hanna GB, Pareskevas P, Aziz O, Boutelle MG, Darzi Aet al., 2008,

  Use of rapid sampling microdialysis for intraoperative monitoring of bowel ischemia (Diseases of the Colon and Rectum DOI: 10.1007/s10350-008-9375-4)

  , Diseases of the Colon and Rectum, Vol: 51, ISSN: 0012-3706
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• Journal article
  Deeba S, Corcoles EP, Hanna BG, Pareskevas P, Aziz O, Boutelle MG, Darzi Aet al., 2008,

  Use of rapid sampling microdialysis for intraoperative monitoring of bowel ischemia

  , DISEASES OF THE COLON & RECTUM, Vol: 51, Pages: 1408-1413, ISSN: 0012-3706
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  • Citations: 35
• Journal article
  Fabricius M, Fuhr S, Willumsen L, Dreier JP, Bhatia R, Boutelle MG, Hartings JA, Bullock R, Strong AJ, Lauritzen Met al., 2008,

  Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain

  , CLINICAL NEUROPHYSIOLOGY, Vol: 119, Pages: 1973-1984, ISSN: 1388-2457
  • Author Web Link
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  • Citations: 156
• Journal article
  Caesar K, Hashemi P, Douhou A, Bonvento G, Boutelle MG, Walls AB, Lauritzen Met al., 2008,

  Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellum in vivo

  , JOURNAL OF PHYSIOLOGY-LONDON, Vol: 586, Pages: 1337-1349, ISSN: 0022-3751
  • Author Web Link
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  • Citations: 83

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