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  • Journal article
    Carhart-Harris RL, Leech R, Erritzoe D, Williams TM, Stone JM, Evans J, Sharp DJ, Feilding A, Wise RG, Nutt DJet al., 2013,

    Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis

    , SCHIZOPHRENIA BULLETIN, Vol: 39, Pages: 1343-1351, ISSN: 0586-7614
  • Journal article
    Hampshire A, MacDonald A, Owen AM, 2013,

    Hypoconnectivity and Hyperfrontality in Retired American Football Players

    , Scientific Reports, Vol: 3
  • Journal article
    Baxter D, Sharp DJ, Feeney C, Papadopoulou D, Ham TE, Jilka S, Hellyer PJ, Patel MC, Bennett AN, Mistlin A, McGilloway E, Midwinter M, Goldstone APet al., 2013,

    Pituitary Dysfunction after Blast Traumatic Brain Injury: The UK BIOSAP Study

    , ANNALS OF NEUROLOGY, Vol: 74, Pages: 527-536, ISSN: 0364-5134
  • Journal article
    Nigmatullina Y, Hellyer PJ, Nachev P, Sharp DJ, Seemungal BMet al., 2013,

    The Neuroanatomical Correlates of Training-Related Perceptuo-Reflex Uncoupling in Dancers

    , Cerebral Cortex, Vol: 25, Pages: 554-562

    Sensory input evokes low-order reflexes and higher-order perceptual responses. Vestibular stimulation elicits vestibular-ocular reflex (VOR) and self-motion perception (e.g., vertigo) whose response durations are normally equal. Adaptation to repeated whole-body rotations, for example, ballet training, is known to reduce vestibular responses. We investigated the neuroanatomical correlates of vestibular perceptuo-reflex adaptation in ballet dancers and controls. Dancers' vestibular-reflex and perceptual responses to whole-body yaw-plane step rotations were: (1) Briefer and (2) uncorrelated (controls' reflex and perception were correlated). Voxel-based morphometry showed a selective gray matter (GM) reduction in dancers' vestibular cerebellum correlating with ballet experience. Dancers' vestibular cerebellar GM density reduction was related to shorter perceptual responses (i.e. positively correlated) but longer VOR duration (negatively correlated). Contrastingly, controls' vestibular cerebellar GM density negatively correlated with perception and VOR. Diffusion-tensor imaging showed that cerebral cortex white matter (WM) microstructure correlated with vestibular perception but only in controls. In summary, dancers display vestibular perceptuo-reflex dissociation with the neuronatomical correlate localized to the vestibular cerebellum. Controls' robust vestibular perception correlated with a cortical WM network conspicuously absent in dancers. Since primary vestibular afferents synapse in the vestibular cerebellum, we speculate that a cerebellar gating of perceptual signals to cortical regions mediates the training-related attenuation of vestibular perception and perceptuo-reflex uncoupling.
  • Journal article
    Braga RM, Sharp DJ, Leeson C, Wise RJS, Leech Ret al., 2013,

    Echoes of the Brain within Default Mode, Association, and Heteromodal Cortices

    , JOURNAL OF NEUROSCIENCE, Vol: 33, Pages: 14031-14039, ISSN: 0270-6474
  • Journal article
    Braga RM, Wilson LR, Sharp DJ, Wise RJS, Leech Ret al., 2013,

    Separable networks for top-down attention to auditory non-spatial and visuospatial modalities

    , NEUROIMAGE, Vol: 74, Pages: 77-86, ISSN: 1053-8119
  • Journal article
    Bonnefond A, Raimondo A, Stutzmann F, Ghoussaini M, Ramachandrappa S, Bersten DC, Durand E, Vatin V, Balkau B, Lantieri O, Raverdy V, Pattou F, Van Hul W, Van Gaal L, Peet DJ, Weill J, Miller JL, Horber F, Goldstone AP, Driscoll DJ, Bruning JB, Meyre D, Whitelaw ML, Froguel Pet al., 2013,

    Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features

    , JOURNAL OF CLINICAL INVESTIGATION, Vol: 123, Pages: 3037-3041, ISSN: 0021-9738
  • Journal article
    Deal CL, Tony M, Hoybye C, Allen DB, Tauber M, Christiansen JSet al., 2013,

    Growth Hormone Research Society Workshop Summary: Consensus Guidelines for Recombinant Human Growth Hormone Therapy in Prader-Willi Syndrome

    , JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 98, Pages: E1072-E1087, ISSN: 0021-972X
  • Journal article
    Pandit AS, Expert P, Lambiotte R, Bonnelle V, Leech R, Turkheimer FE, Sharp DJet al., 2013,

    Traumatic brain injury impairs small-world topology

    , NEUROLOGY, Vol: 80, Pages: 1826-1833, ISSN: 0028-3878

    Objective: We test the hypothesis that brain networks associated with cognitive function shift away from a “small-world” organization following traumatic brain injury (TBI).Methods: We investigated 20 TBI patients and 21 age-matched controls. Resting-state functional MRI was used to study functional connectivity. Graph theoretical analysis was then applied to partial correlation matrices derived from these data. The presence of white matter damage was quantified using diffusion tensor imaging.Results: Patients showed characteristic cognitive impairments as well as evidence of damage to white matter tracts. Compared to controls, the graph analysis showed reduced overall connectivity, longer average path lengths, and reduced network efficiency. A particular impact of TBI is seen on a major network hub, the posterior cingulate cortex. Taken together, these results confirm that a network critical to cognitive function shows a shift away from small-world characteristics.Conclusions: We provide evidence that key brain networks involved in supporting cognitive function become less small-world in their organization after TBI. This is likely to be the result of diffuse white matter damage, and may be an important factor in producing cognitive impairment after TBI.
  • Journal article
    Cegla J, Jones B, Seyani L, Papadoulou D, Wynne K, Martin NM, Meeran K, Chapman R, Donaldson M, Goldstone AP, Tan Tet al., 2013,

    Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism

    , CLINICAL ENDOCRINOLOGY, Vol: 78, Pages: 738-742, ISSN: 0300-0664

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