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  • Journal article
    Ham T, Leff A, de Boissezon X, Joffe A, Sharp DJet al., 2013,

    Cognitive Control and the Salience Network: An Investigation of Error Processing and Effective Connectivity

    , JOURNAL OF NEUROSCIENCE, Vol: 33, Pages: 7091-+, ISSN: 0270-6474
  • Journal article
    Schweizer S, Grahn J, Hampshire A, Mobbs D, Dalgleish Tet al., 2013,

    Training the emotional brain: improving affective control through emotional working memory training.

    , J Neurosci, Vol: 33, Pages: 5301-5311

    Affective cognitive control capacity (e.g., the ability to regulate emotions or manipulate emotional material in the service of task goals) is associated with professional and interpersonal success. Impoverished affective control, by contrast, characterizes many neuropsychiatric disorders. Insights from neuroscience indicate that affective cognitive control relies on the same frontoparietal neural circuitry as working memory (WM) tasks, which suggests that systematic WM training, performed in an emotional context, has the potential to augment affective control. Here we show, using behavioral and fMRI measures, that 20 d of training on a novel emotional WM protocol successfully enhanced the efficiency of this frontoparietal demand network. Critically, compared with placebo training, emotional WM training also accrued transfer benefits to a "gold standard" measure of affective cognitive control-emotion regulation. These emotion regulation gains were associated with greater activity in the targeted frontoparietal demand network along with other brain regions implicated in affective control, notably the subgenual anterior cingulate cortex. The results have important implications for the utility of WM training in clinical, prevention, and occupational settings.
  • Journal article
    Ham TE, de Boissezon X, Leff A, Beckmann C, Hughes E, Kinnunen KM, Leech R, Sharp DJet al., 2013,

    Distinct Frontal Networks Are Involved in Adapting to Internally and Externally Signaled Errors

    , CEREBRAL CORTEX, Vol: 23, Pages: 703-713, ISSN: 1047-3211
  • Journal article
    Vijayan R, Scott G, 2013,

    An approach to the obstructive colleague

    , British Medical Journal, Vol: 347, ISSN: 0007-1447
  • Journal article
    Vijayan R, Scott G, 2013,

    Doctor, interrupted

    , British Medical Journal, Vol: 346, ISSN: 0007-1447
  • Journal article
    Kolias AG, Li LM, Guilfoyle MR, Timofeev I, Corteen EA, Pickard JD, Kirkpatrick PJ, Menon DK, Hutchinson PJet al., 2013,

    Decompressive craniectomy for acute subdural hematomas: time for a randomized trial

    , Acta Neurochirurgica, Vol: 155, Pages: 187-188, ISSN: 0001-6268
  • Journal article
    Hampshire A, Parkin BL, Cusack R, Fernández Espejoa D, Allanson J, Kamau E, Pickard JD, Owen AMet al., 2013,

    Assessing residual reasoning ability in overtly non-communicative patients using fMRI

    , NeuroImage: Clinical, Vol: 2, Pages: 174-183
  • Journal article
    Fallon SJ, Hampshire A, Williams-Gray CH, Barker RA, Owen AMet al., 2013,

    Putative cortical dopamine levels affect cortical recruitment during planning

    , Neuropsychologia, ISSN: 1873-3514

    Planning, the decomposition of an ultimate goal into a number of sub-goals is critically dependent upon fronto-striatal dopamine (DA) levels. Here, we examined the extent to which the val158met polymorphism in the catechol O-methyltransferase (COMT) gene, which is thought to primarily alter cortical DA levels, affects performance and fronto-parietal activity during a planning task (Tower of London). COMT genotype was found to modulate activity in the left superior posterior parietal cortex (SPC) during planning, relative to subtracting, trials. Specifically, left SPC blood oxygenation level-dependent (BOLD) response was reduced in groups with putatively low or high cortical DA levels (COMT homozygotes) relative to those with intermediate cortical DA levels (COMT heterozygotes). These set of results are argued to occur either due to differences in neuronal processing in planning (and perhaps subtracting) caused by the COMT genotype and/or the cognitively heterogeneous nature of the TOL, which allows different cognitive strategies to be used whilst producing indistinguishable behavioural performance in healthy adults. The implications of this result for our understanding of COMT's effect on cognition in health and disease are discussed.
  • Journal article
    Cinan S, Özen G, Hampshire A, 2013,

    Confirmatory factor analysis on separability of planning and insight constructs

    , Journal of Cognitive Psychology
  • Journal article
    Hellyer PJ, Leech R, Ham TE, Bonnelle V, Sharp DJet al., 2013,

    Individual prediction of white matter injury following traumatic brain injury

    , Annals of Neurology, ISSN: 1531-8249

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