The Structural Frontiers of Neuroscience
Organised by
Prof Annalisa Pastore
Visiting Professor, Imperial College London
Dr Yu Ye
Lecturer, Imperial College London
Dr Michael Grange
Group Leader, Rosalind Franklin Institute
19-20 November 2024
The Stadium Room, Scale Space, White City, 58 Wood Lane, London W12 7RZ
Protein structure underpins function and dysfunction in molecular processes. Seventy years since the first protein and DNA structures, we are now for the first time able to consider studying the structure of molecules directly in situ and to correlate atomic resolution with information obtained at the cellular, tissue and organ levels.
In this two-day workshop, jointly hosted by Imperial College London, the UK DRI, and the Rosalind Franklin Institute, we will delve into recent advances in the field and discuss how these novel technologies address key neuroscientific research challenges. There will be talks from world-leading experts who have made significant contributions to Structural Neuroscience, spanning atomic to organismal insights, as well as a poster session and drinks reception to catalyse collaborations. See the full list of speakers below.
Aims
- Discuss the frontier of structural biology in Neurosciences and Neurodegeneration, presenting the leading edge of current structural biology approaches to investigate neuronal function/misfunction.
- Reflect on the gaps in understanding that nascent structural approaches may address, and how a new era may be entered into that will permit a multiscale understanding of neuronal processes at different levels of resolution.
Any questions?
Please contact co-organiser Michael Grange (michael.grange@rfi.ac.uk) with any queries.
Programme
Day 1
Molecules and Atoms
09.45-10.20 Sandra Ribeiro Macedo (Porto)
10.20-10.55 Sjors Scheres (Cambridge) SPA
10.55-11.15 Coffee break
11.15-11.50 Sheena Radford (Leeds) Biophys
11.50-12.25 Lisa Cabrita (London) Xtals/Biophys
12.25-13.00 David Klenerman (Cambridge) Microscopy
13.00-13.15 Selected Talk
13.15-14.00 Lunch
Enlarging the perspective
14.00-14.35 Louise Serpell (Brighton)
14.35-15.10 Elena Seiderake (Oxford)
15.10-15.30 Coffee break
15.30-16.05 Benjamin Ryskeldi-Falcon (LMB)
16.05-16.40 Carol Robinson (Oxford)
16.40-17.00 Selected Talk
17.00-19.00 Poster session, with cheese and wine
19.00-21.30 Buffet dinner and entertainment
Day 2
Structural approaches in context
09.00-09.35 Pete Cullen (Bristol)
09.35-10.10 Ruben Fernandez-Busnadiego (Göttingen)
10.10-10.45 Sarah Mizielinska (London)
10.45-11.10 Coffee break
11.10-11.45 Naoko Mizuno (NIH)
11.45-12.20 Tim Bartels (DRI)
12.20-12.40 Selected Talk
12.40-13.30 Lunch
Multiscale imaging and neurons
13.30-14.05 Alexandra Pacureanu (ESRF)
14.05-14.40 Radu Aricescu (LMB)
14.40-15.00 Coffee break
15.00-15.35 Judy Kim (RFI)
15.35-16.10 Peter Lee (London)
16.10-16.25 Selected Talk
16.25-16.30 Wrap up
Speakers
Dr Alexandra Pacureanu
ESRF, the European Synchrotron
View professional webpage
Dr Benjamin Ryskeldi-Falcon
MRC Laboratory of Molecular Biology, Cambridge, UK
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Dr Claire Walsh
University College London
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2
Professor Sir David Klenerman
UK DRI at Cambridge
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Professor Elena Seiradake
University of Oxford
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Dr Janet Kumita
University of Cambridge
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3
Dr Judy Kim
The Rosalind Franklin Institute
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Dr Lisa Cabrita
University College London
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Professor Louise Serpell
University of Sussex
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4
Dr Naoko Mizuno
National Heart, Lung and Blood Institute
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Professor Perdita Barran
University of Manchester
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Professor Peter Cullen
University of Bristol
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5
Professor Radu Aricescu
MRC Laboratory of Molecular Biology
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Professor Rubén Fernández-Busnadiego
University Medical Centre, University of Göttingen
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Professor Sandra Ribeiro
Instituto de Investigação e Inovação em Saúde, University of Portugal
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6
Dr Sarah Mizielinska
UK DRI at King's College London
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Dr Sjors Scheres
MRC Laboratory of Molecular Biology
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Dr Tim Bartels
UK DRI at UCL
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