Publications

Search or filter publications

Filter by type:

Filter by publication type

Filter by year:

to

Results

  • Showing results for:
  • Reset all filters

Search results

  • Journal article
    Murphy N, Cross AJ, Abubakar M, Jenab M, Aleksandrova K, Boutron-Ruault MC, Dossus L, Racine A, Kühn T, Katzke VA, Tjønneland A, Petersen KE, Overvad K, Quirós JR, Jakszyn P, Molina-Montes E, Dorronsoro M, Huerta JM, Barricarte A, Khaw KT, Wareham N, Travis RC, Trichopoulou A, Lagiou P, Trichopoulos D, Masala G, Krogh V, Tumino R, Vineis P, Panico S, Bueno-de-Mesquita HB, Siersema PD, Peeters PH, Ohlsson B, Ericson U, Palmqvist R, Nyström H, Weiderpass E, Skeie G, Freisling H, Kong SY, Tsilidis K, Muller DC, Riboli E, Gunter MJet al., 2016,

    A nested case–control study of metabolically defined body size phenotypes and risk of colorectal cancer in the European prospective investigation into cancer and nutrition (EPIC)

    , Plos Medicine, Vol: 13, ISSN: 1549-1676
  • Journal article
    Hudry B, Khadayate S, Miguel-Aliaga I, 2016,

    The sexual identity of adult intestinal stem cells controls organ size and plasticity.

    , Nature, Vol: 530, Pages: 344-348, ISSN: 1476-4687

    Sex differences in physiology and disease susceptibility are commonly attributed to developmental and/or hormonal factors, but there is increasing realization that cell-intrinsic mechanisms play important and persistent roles. Here we use the Drosophila melanogaster intestine to investigate the nature and importance of cellular sex in an adult somatic organ in vivo. We find that the adult intestinal epithelium is a cellular mosaic of different sex differentiation pathways, and displays extensive sex differences in expression of genes with roles in growth and metabolism. Cell-specific reversals of the sexual identity of adult intestinal stem cells uncovers the key role this identity has in controlling organ size, reproductive plasticity and response to genetically induced tumours. Unlike previous examples of sexually dimorphic somatic stem cell activity, the sex differences in intestinal stem cell behaviour arise from intrinsic mechanisms that control cell cycle duration and involve a new doublesex- and fruitless-independent branch of the sex differentiation pathway downstream of transformer. Together, our findings indicate that the plasticity of an adult somatic organ is reversibly controlled by its sexual identity, imparted by a new mechanism that may be active in more tissues than previously recognized.
  • Journal article
    Devaux M, Sassi F, 2016,

    Social disparities in hazardous alcohol use: self-report bias may lead to incorrect estimates

    , EUROPEAN JOURNAL OF PUBLIC HEALTH, Vol: 26, Pages: 129-134, ISSN: 1101-1262
  • Journal article
    Sassi F, 2016,

    Taxing sugar

    , BMJ-BRITISH MEDICAL JOURNAL, Vol: 352, ISSN: 0959-535X
  • Book chapter
    Childs PRN, 2016,

    Nanoscale thermometry and temperature measurement

    , RSC Nanoscience and Nanotechnology No. 38, Thermometry at the Nanoscale: Techniques and Selected Applications., Editors: Carlos, Palacio, Publisher: Royal Society of Chemistry, Pages: 3-22, ISBN: 9781849739047

    Temperature measurement on the nanoscale is important for applications such as detecting the local temperature changes associated with microelectronics, optics, microfluidics, chemical reaction and biochemical processes, such as living cells and nanomedicine. The drive for information at this scale comes from the electronics industry, materials development and the biosector, combined with rapid development in enabling technologies such as sensor integration and manufacture. The scale of the application and the nature of physical probes distorting the local temperature field due to thermal conduction effects, or optical probes due to thermal radiation heat transfer or energy associated with excitation of a medium, means that great care needs to be taken in order to provide meaningful measurements. This chapter provides an overview of temperature measurement principles along with a review of some of the principal and emerging technologies for nanoscale temperature measurement.
  • Journal article
    Damiani G, Basso D, Acampora A, Bianchi CBNA, Silvestrini G, Frisicale EM, Sassi F, Ricciardi Wet al., 2015,

    The impact of level of education on adherence to breast and cervical cancer screening: Evidence from a systematic review and meta-analysis

    , PREVENTIVE MEDICINE, Vol: 81, Pages: 281-289, ISSN: 0091-7435
  • Journal article
    Chambers ES, Viardot A, Psichas A, Morrison DJ, Murphy KG, Zac-Varghese SEK, MacDougall K, Preston T, Tedford C, Finlayson GS, Blundell JE, Bell JD, Thomas EL, Mt-Isa S, Ashby D, Gibson GR, Kolida S, Dhillo WS, Bloom SR, Morley W, Clegg S, Frost Get al., 2015,

    Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

    , Gut, Vol: 64, Pages: 1744-1754, ISSN: 0017-5749

    Objective The colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play an important role in appetite regulation. We hypothesised that colonic delivery of propionate would increase peptide YY (PYY) and glucagon like peptide-1 (GLP-1) secretion in humans, and reduce energy intake and weight gain in overweight adults.Design To investigate whether propionate promotes PYY and GLP-1 secretion, a primary cultured human colonic cell model was developed. To deliver propionate specifically to the colon, we developed a novel inulin-propionate ester. An acute randomised, controlled cross-over study was used to assess the effects of this inulin-propionate ester on energy intake and plasma PYY and GLP-1 concentrations. The long-term effects of inulin-propionate ester on weight gain were subsequently assessed in a randomised, controlled 24-week study involving 60 overweight adults.Results Propionate significantly stimulated the release of PYY and GLP-1 from human colonic cells. Acute ingestion of 10 g inulin-propionate ester significantly increased postprandial plasma PYY and GLP-1 and reduced energy intake. Over 24 weeks, 10 g/day inulin-propionate ester supplementation significantly reduced weight gain, intra-abdominal adipose tissue distribution, intrahepatocellular lipid content and prevented the deterioration in insulin sensitivity observed in the inulin-control group.Conclusions These data demonstrate for the first time that increasing colonic propionate prevents weight gain in overweight adult humans.
  • Journal article
    Miguel-Aliaga I, 2015,

    Cell scientist to watch - Irene Miguel-Aliaga

    , Journal of Cell Science, Vol: 128, Pages: 3519-3520, ISSN: 1477-9137
  • Journal article
    Reiff T, Jacobson J, Cognigni P, Antonello Z, Ballesta E, Tan KJ, Yew JY, Dominguez M, Miguel-Aliaga Iet al., 2015,

    Endocrine remodelling of the adult intestine sustains reproduction in Drosophila.

    , eLife, Vol: 4, ISSN: 2050-084X

    The production of offspring is energetically costly and relies on incompletely understood mechanisms that generate a positive energy balance. In mothers of many species, changes in key energy-associated internal organs are common yet poorly characterised functionally and mechanistically. In this study, we show that, in adult Drosophila females, the midgut is dramatically remodelled to enhance reproductive output. In contrast to extant models, organ remodelling does not occur in response to increased nutrient intake and/or offspring demands, but rather precedes them. With spatially and temporally directed manipulations, we identify juvenile hormone (JH) as an anticipatory endocrine signal released after mating. Acting through intestinal bHLH-PAS domain proteins Methoprene-tolerant (Met) and Germ cell-expressed (Gce), JH signals directly to intestinal progenitors to yield a larger organ, and adjusts gene expression and sterol regulatory element-binding protein (SREBP) activity in enterocytes to support increased lipid metabolism. Our findings identify a metabolically significant paradigm of adult somatic organ remodelling linking hormonal signals, epithelial plasticity, and reproductive output.
  • Journal article
    Cecchini M, Sassi F, 2015,

    Preventing Obesity in the USA: Impact on Health Service Utilization and Costs

    , PHARMACOECONOMICS, Vol: 33, Pages: 765-776, ISSN: 1170-7690

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wwwtest.imperial.ac.uk:80/respub/WEB-INF/jsp/search-t4-html.jsp Request URI: /respub/WEB-INF/jsp/search-t4-html.jsp Query String: id=838&limit=10&page=5&respub-action=search.html Current Millis: 1759579148108 Current Time: Sat Oct 04 12:59:08 BST 2025