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Principles of Biomolecular Systems

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Principles of Biomolecular Systems

Engineering at the interface of biology, chemistry and physics

About us

We are an interdisciplinary group of researchers led by Dr Thomas Ouldridge, based in the Department of Bioengineering at Imperial College London.

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Our Research

The group probes the fundamental principles underlying complex biochemical systems through theoretical modelling, simulation and experiment. In particular, we focus on the interplay between the detailed biochemistry and the overall output of a process such as sensing, replication or self-assembly. We're inspired by natural systems, and aim to explore the possibilities of engineering artificial analogs.

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New PhD opportunity

We're advertising for a new PhD student, to work on the theory of non-equilibrium molecular information processing

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Nanoscale paper from Francesca on RNA/DNA hybrid strand displacement

Congratulations to Francesca, who has published her work on the strong sequence dependence in RNA/DNA hybrid strand displacement

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Sing Ming Chan joins the group

Welcome Sing Ming Chan, who will work on strategy for writing and re-writing data into DNA nanostructures

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JACS paper from Rakesh on kinetic proofreading

Congratulations to Rakesh, who has published his work on the first synthetic kinetic proofreading system in JACS

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