@article{Luppi:2022:10.1101/2022.07.12.499688,
author = {Luppi, AI and Hansen, JY and Adapa, R and Carhart-Harris, RL and Roseman, L and Golkowski, D and Ranft, A and Ilg, R and Jordan, D and Peattie, ARD and Manktelow, AE and de, Araujo DB and Sensi, SL and Owen, AM and Naci, L and Menon, DK and Misic, B and Stamatakis, EA},
doi = {10.1101/2022.07.12.499688},
title = {Mapping Pharmacologically-induced Functional Reorganisation onto the Brain’s Neurotransmitter Landscape},
url = {http://dx.doi.org/10.1101/2022.07.12.499688},
year = {2022}
}

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TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain’s rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically-induced macroscale functional reorganisation, by relating the regional distribution of 18 neurotransmitter receptors and transporters obtained from Positron Emission Tomography, and the regional changes in functional MRI connectivity induced by 7 different mind-altering drugs including anaesthetics, psychedelics, and cognitive enhancers. Our results reveal that psychoactive drugs exert their effects on brain function by engaging multiple neurotransmitter systems. Intriguingly, the effects of both anaesthetics and psychedelics on brain function, though opposite, are organised along hierarchical gradients of brain structure and function. Finally, we show that regional co-susceptibility to pharmacological interventions recapitulates co-susceptibility to disorder-induced structural alterations. Collectively, these results highlight rich statistical patterns relating molecular chemoarchitecture and drug-induced reorganisation of the brain’s functional architecture.</jats:p>
AU  - Luppi,AI
AU  - Hansen,JY
AU  - Adapa,R
AU  - Carhart-Harris,RL
AU  - Roseman,L
AU  - Golkowski,D
AU  - Ranft,A
AU  - Ilg,R
AU  - Jordan,D
AU  - Peattie,ARD
AU  - Manktelow,AE
AU  - de,Araujo DB
AU  - Sensi,SL
AU  - Owen,AM
AU  - Naci,L
AU  - Menon,DK
AU  - Misic,B
AU  - Stamatakis,EA
DO  - 10.1101/2022.07.12.499688
PY  - 2022///
TI  - Mapping Pharmacologically-induced Functional Reorganisation onto the Brain’s Neurotransmitter Landscape
UR  - http://dx.doi.org/10.1101/2022.07.12.499688
ER  - 

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