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Journal articleDavis S, Hu Y, Jiang N, et al., 2022,
Reversible photonic hydrogel sensors via holographic interference lithography
, Biosensors and Bioelectronics, ISSN: 0956-5663 -
Journal articleRabbi F, Dabbagh SR, Angin P, et al., 2022,
Deep learning-enabled technologies for bioimage analysis.
, Micromachines (Basel), Vol: 13, Pages: 1-28, ISSN: 2072-666XDeep learning (DL) is a subfield of machine learning (ML), which has recently demonstrated its potency to significantly improve the quantification and classification workflows in biomedical and clinical applications. Among the end applications profoundly benefitting from DL, cellular morphology quantification is one of the pioneers. Here, we first briefly explain fundamental concepts in DL and then we review some of the emerging DL-enabled applications in cell morphology quantification in the fields of embryology, point-of-care ovulation testing, as a predictive tool for fetal heart pregnancy, cancer diagnostics via classification of cancer histology images, autosomal polycystic kidney disease, and chronic kidney diseases.
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Journal articleAlam F, Salih AE, Elsherif M, et al., 2022,
3D printed contact lenses for the management of color blindness
, Additive Manufacturing, Vol: 49, Pages: 102464-102464, ISSN: 2214-8604 -
Journal articleDong J, Yetisen AK, Zhao C, et al., 2021,
Single-Shot High-Throughput Phase Imaging with Multibeam Array Interferometric Microscopy
, ACS PHOTONICS, Vol: 8, Pages: 3536-3547, ISSN: 2330-4022 -
Journal articleRuiz-Esparza GU, Wang X, Zhang X, et al., 2021,
Nanoengineered shear-thinning hydrogel barrier for preventing postoperative abdominal adhesions
, Nano-Micro Letters, Vol: 13, Pages: 1-16, ISSN: 2150-5551More than 90% of surgical patients develop postoperative adhesions, and the incidence of hospital re-admissions can be as high as 20%. Current adhesion barriers present limited efficacy due to difficulties in application and incompatibility with minimally invasive interventions. To solve this clinical limitation, we developed an injectable and sprayable shear-thinning hydrogel barrier (STHB) composed of silicate nanoplatelets and poly(ethylene oxide). We optimized this technology to recover mechanical integrity after stress, enabling its delivery though injectable and sprayable methods. We also demonstrated limited cell adhesion and cytotoxicity to STHB compositions in vitro. The STHB was then tested in a rodent model of peritoneal injury to determine its efficacy preventing the formation of postoperative adhesions. After two weeks, the peritoneal adhesion index was used as a scoring method to determine the formation of postoperative adhesions, and STHB formulations presented superior efficacy compared to a commercially available adhesion barrier. Histological and immunohistochemical examination showed reduced adhesion formation and minimal immune infiltration in STHB formulations. Our technology demonstrated increased efficacy, ease of use in complex anatomies, and compatibility with different delivery methods, providing a robust universal platform to prevent postoperative adhesions in a wide range of surgical interventions.
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Journal articleDavies S, Hu Y, Jiang N, et al., 2021,
Holographic sensors in biotechnology
, Advanced Functional Materials, Vol: 31, Pages: 1-24, ISSN: 1616-301XAs populations expand worldwide, medical care will need to diversify its data collection techniques to be able to provide adequate healthcare to global populations, this could be achieved through point-of-care analysis by wearable analytical devices. Holographic sensors are reusable optical biosensors with the capability to continuously monitor variations, generating the prospect of in vivo monitoring of patient homeostasis. Holographic optical sensors have emerged as an opportunity for low cost and real-time point-of-care analysis of biomarkers to be realised. This review aims to summarise the fundamentals and fabrications of holographic sensors; a key focus will be directed to examining the biotechnology applications in a variety of analytical settings. Techniques covered include surface relief gratings, inverse opals, metal nanoparticle and nanoparticle free holographic sensors. This article provides an overview of holographic biosensing in applications such as pH, alcohol, ion, glucose, and drug detection, alongside antibiotic monitoring. Details of developments in fabrication and sensitising techniques will be examined and how they have improved the applicability of holographic sensors to point-of-care analytics. Although holographic sensors have made significant progress in recent years, the current challenges, and requirements for advanced holographic technology to fulfil their future potential applications in biomedical devices will be discussed.
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Journal articleSalih AE, Shanti A, Elsherif M, et al., 2021,
Silver Nanoparticle-Loaded Contact Lenses for Blue-Yellow Color Vision Deficiency
, PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, Vol: 219, ISSN: 1862-6300 -
Journal articlePazos MD, Hu Y, Elani Y, et al., 2021,
Tattoo inks for optical biosensing in interstitial fluid
, Advanced Healthcare Materials, Vol: 10, Pages: 1-22, ISSN: 2192-2640The persistence of traditional tattoo inks presents an advantage for continuous andlong-term health monitoring in point of care devices. The replacement of tattoo pigments withoptical biosensors aims a promising alternative for monitoring blood biomarkers. Tattoo inksfunctionalization enables the control of interstitial biomarkers with correlated concentrations inplasma, to diagnose diseases, evaluate progression, and prevent complications associated withphysio pathological disorders or medication mismatches. The specific biomarkers in interstitialfluid provide a new source of information, especially for skin diseases. The study of tattoo inksdisplays insufficient regulation in their composition, a lack of reports of the relatedcomplications and a need for further studies on their degradation kinetics. This review focuseson tattoo optical biosensors for monitoring dermal interstitial biomarkers and discusses theyclinical advantages and main challenges for in vivo implantation. Tattoo functionalizationprovides a minimally invasive, reversible, biocompatible, real-time sensing with long-termpermanence and multiplexing capabilities for the control, diagnosis, and prevention of illness;it enables self-controlling management by the patient, but also the possibility of sending therecords to the doctor.
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Journal articleAli M, Alam F, Ahmed I, et al., 2021,
3D printing of Fresnel lenses with wavelength selective tinted materials
, ADDITIVE MANUFACTURING, Vol: 47, ISSN: 2214-8604 -
Journal articleWu Y, Szymanska M, Hu Y, et al., 2021,
Measures of disease activity in glaucoma
, BIOSENSORS & BIOELECTRONICS, Vol: 196, ISSN: 0956-5663- Author Web Link
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- Citations: 3
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Journal articleMoreddu R, Mahmoodi N, Kassanos P, et al., 2021,
Stretchable Nanostructures as Optomechanical Strain Sensors for Ophthalmic Applications
, ACS APPLIED POLYMER MATERIALS, Vol: 3, Pages: 5416-5424, ISSN: 2637-6105 -
Journal articleElsherif M, Alam F, Salih AE, et al., 2021,
Wearable Bifocal Contact Lens for Continual Glucose Monitoring Integrated with Smartphone Readers
, SMALL, Vol: 17, ISSN: 1613-6810 -
Journal articleShi Y, Jiang N, Bikkannavar P, et al., 2021,
Ophthalmic sensing technologies for ocular disease diagnostics
, ANALYST, Vol: 146, Pages: 6416-6444, ISSN: 0003-2654 -
Journal articleBalbach S, Jiang N, Moreddu R, et al., 2021,
Smartphone-based colorimetric detection system for portable health tracking
, Analytical Methods: advancing methods and applications, Vol: 13, Pages: 4361-4369, ISSN: 1759-9660Colorimetric tests for at-home health monitoring became popular 50 years ago with the advent of the urinalysis test strips, due to their reduced costs, practicality, and ease of operation. However, developing digital systems that can interface these sensors in an efficient manner remains a challenge. Efforts have been put towards the development of portable optical readout systems, such as smartphones. However, their use in daily settings is still limited by their error-prone nature associated to optical noise from the ambient lighting, and their low sensitivity. Here, a smartphone application (Colourine) to readout colorimetric signals was developed on Android OS and tested on commercial urinalysis test strips for pH, proteins, and glucose detection. The novelty of this approach includes two features: a pre-calibration step where the user is asked to take a photo of the commercial reference chart, and a CIE-RGB-to-HSV color space transformation of the acquired data. These two elements allow the background noise given by environmental lighting to be minimized. The sensors were characterized in the ambient light range 100–400 lx, yielding a reliable output. Readouts were taken from urine strips in buffer solutions of pH (5.0–9.0 units), proteins (0–500 mg dL−1) and glucose (0–1000 mg dL−1), yielding a limit of detection (LOD) of 0.13 units (pH), 7.5 mg dL−1 (proteins) and 22 mg dL−1 (glucose), resulting in an average LOD decrease by about 2.8 fold compared to the visual method.
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Journal articleJiang N, Flyax S, Kurz W, et al., 2021,
Intracranial Sensors for Continuous Monitoring of Neurophysiology
, ADVANCED MATERIALS TECHNOLOGIES, Vol: 6, ISSN: 2365-709X -
Journal articleMoreddu R, Nasrollahi V, Kassanos P, et al., 2021,
Lab-on-a-Contact Lens Platforms Fabricated by Multi-Axis Femtosecond Laser Ablation
, SMALL, Vol: 17, ISSN: 1613-6810 -
Journal articleAlseed MM, Syed H, Onbasli MC, et al., 2021,
Design and adoption of low-cost point-of-care diagnostic devices: Syrian case
, Micromachines, Vol: 12, Pages: 1-11, ISSN: 2072-666XCivil wars produce immense humanitarian crises, causing millions of individuals to seek refuge in other countries. The rate of disease prevalence has inclined among the refugees, increasing the cost of healthcare. Complex medical conditions and high numbers of patients at healthcare centers overwhelm the healthcare system and delay diagnosis and treatment. Point-of-care (PoC) testing can provide efficient solutions to high equipment cost, late diagnosis, and low accessibility of healthcare services. However, the development of PoC devices in developing countries is challenged by several barriers. Such PoC devices may not be adopted due to prejudices about new technologies and the need for special training to use some of these devices. Here, we investigated the concerns of end users regarding PoC devices by surveying healthcare workers and doctors. The tendency to adopt PoC device changes is based on demographic factors such as work sector, education, and technology experience. The most apparent concern about PoC devices was issues regarding low accuracy, according to the surveyed clinicians.
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Journal articleDong X, Yetisen AK, Dong J, et al., 2021,
Hyperspectral Fingerprints for Atomic Layer Mapping of Two-Dimensional Materials with Single-Layer Accuracy
, JOURNAL OF PHYSICAL CHEMISTRY C, Vol: 125, Pages: 16583-16590, ISSN: 1932-7447 -
Journal articleMontelongo A, Becker JL, Roman R, et al., 2021,
The management of COVID-19 cases through telemedicine in Brazil
, PLoS One, Vol: 16, Pages: 1-14, ISSN: 1932-6203In Dec 2020 Brazil became one of the worldwide epicenters of the COVID-19 pandemic with more than 7.2M reported cases. Brazil has a large territory with unequal distribution of healthcare resources including physicians. Resource limitation has been one of the main factors hampering Brazil’s response to the COVID-19 crisis. Telemedicine has been an effective approach for COVID-19 management as it allows to reduce the risk of cross-contamination and provides support to remote rural locations. Here we present the analyses of teleconsultations from a countrywide telemedicine service (TelessáudeRS-UFRGS, TRS), that provides physician-to-physician remote support during the COVID-19 pandemic in Brazil. We performed a descriptive analysis of the teleconsultation incoming calls and a text analysis from the call transcripts. Our findings indicate that TRS teleconsultations in Brazil experienced an exponential increment of 802.% during a period of 6 days, after the first death due to COVID-19 was reported. However, the number of teleconsultations cases decreased over time, despite the number of reported COVID-19 cases continuously increasing. The results also showed that physicians in low-income municipalities, based on GDP per capita, are less likely to consult the telemedicine service despite facing higher rates of COVID-19 cases. The text analysis of call transcripts from medical teleconsultations showed that the main concern of physicians were “asymptomatic” patients. We suggest an immediate reinforcement of telehealth services in the regions of lower income as a strategy to support COVID-19 management.
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Journal articleSavariraj AD, Salih A, Alam F, et al., 2021,
Ophthalmic sensors and drug delivery
, ACS Sensors, Vol: 6, Pages: 2046-2076, ISSN: 2379-3694Advances in multifunctional materials and technologies have allowed contact lenses to serve as wearable devices for continuous monitoring of physiological parameters and delivering drugs for ocular diseases. Since the tear fluids comprise a library of biomarkers, direct measurement of different parameters such as concentration of glucose, urea, proteins, nitrite, and chloride ions, intraocular pressure (IOP), corneal temperature, and pH can be carried out non-invasively using contact lens sensors. Microfluidic contact lens sensor based colorimetric sensing and liquid control mechanisms enable the wearers to perform self-examinations at home using smartphones. Furthermore, drug-laden contact lenses have emerged as delivery platforms using a low dosage of drugs with extended residence time and increased ocular bioavailability. This review provides an overview of contact lenses for ocular diagnostics and drug delivery applications. The designs, working principles, and sensing mechanisms of sensors and drug delivery systems are reviewed. The potential applications of contact lenses in point-of-care diagnostics and personalized medicine, along with the significance of integrating multiplexed sensing units together with drug delivery systems, have also been discussed.
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ReportBrophy K, Davies S, Olenik S, et al., 2021,
The future of wearable technologies
, Briefing Paper -
Journal articleJiang N, Tansukawat ND, Gonzalez-Macia L, et al., 2021,
Low-Cost Optical Assays for Point-of-Care Diagnosis in Resource-Limited Settings
, ACS SENSORS, Vol: 6, Pages: 2108-2124, ISSN: 2379-3694 -
Journal articleSarabi MR, Ahmadpour A, Yetisen AK, et al., 2021,
Finger-Actuated Microneedle Array for Sampling Body Fluids
, APPLIED SCIENCES-BASEL, Vol: 11 -
Journal articleZhang Y, Jiang N, Yetisen AK, 2021,
Brain neurochemical monitoring
, BIOSENSORS & BIOELECTRONICS, Vol: 189, ISSN: 0956-5663- Author Web Link
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- Citations: 8
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Journal articleLiu Q, Tian J, Tian Y, et al., 2021,
Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy
, ACTA BIOMATERIALIA, Vol: 127, Pages: 287-297, ISSN: 1742-7061- Author Web Link
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- Citations: 5
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Journal articleYin Y, Wang W, Shao Q, et al., 2021,
Pentapeptide IKVAV-engineered hydrogels for neural stem cell attachment
, BIOMATERIALS SCIENCE, Vol: 9, Pages: 2887-2892, ISSN: 2047-4830 -
Journal articleYu Z, Jiang N, Kazarian SG, et al., 2021,
Optical sensors for continuous glucose monitoring
, Progress in Biomedical Engineering, Vol: 3, Pages: 022004-022004<jats:title>Abstract</jats:title> <jats:p>For decades, diabetes mellitus has been of wide concern with its high global prevalence, resulting in increasing social and financial burdens for individuals, clinical systems and governments. Continuous glucose monitoring (CGM) has become a popular alternative to the portable finger-prick glucometers available in the market for the convenience of diabetic patients. Hence, it has attracted much interest in various glucose sensing technologies to develop novel glucose sensors with better performance and longer lifetime, especially non-invasive or minimally invasive glucose sensing. Effort has also been put into finding biocompatible materials for implantable applications to achieve effective <jats:italic>in vivo</jats:italic> CGM. Here, we review the state-of-the-art researches in the field of CGM. The currently commercially available CGM technologies have been analyzed and a summary is provided of the potential types of recently researched non-invasive glucose monitors. Furthermore, the challenges and advances towards implantable applications have also been introduced and discussed, especially the novel biocompatible hydrogel aimed at minimizing the adverse impact from foreign-body response. In addition, a large variety of promising glucose-sensing technologies under research have been reviewed, from traditional electrochemical-based glucose sensors to novel optical and other electrical glucose sensors. The recent development and achievement of the reviewed glucose sensing technologies are discussed, together with the market analysis in terms of the statistical data for the newly published patents in the related field. Thus, the promising direction for future work in this field could be concluded.</jats:p>
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Journal articleSalih AE, Elsherif M, Alam F, et al., 2021,
Gold nanocomposite contact Lenses for color blindness management
, ACS Nano, Vol: 15, Pages: 4870-4880, ISSN: 1936-0851Color vision deficiency (CVD) is an ocular congenital disorder that affects 8% of males and 0.5% of females. The most prevalent form of color vision deficiency (color blindness) affects protans and deutans and is more commonly known as “red–green color blindness”. Since there is no cure for this disorder, CVD patients opt for wearables that aid in enhancing their color perception. The most common wearable used by CVD patients is a form of tinted glass/lens. Those glasses filter out the problematic wavelengths (540–580 nm) for the red–green CVD patients using organic dyes. However, few studies have addressed the fabrication of contact lenses for color vision deficiency, and several problems related to their effectiveness and toxicity were reported. In this study, gold nanoparticles are integrated into contact lens material, thus forming nanocomposite contact lenses targeted for red–green CVD application. Three distinct sets of nanoparticles were characterized and incorporated with the hydrogel material of the lenses (pHEMA), and their resulting optical and material properties were assessed. The transmission spectra of the developed nanocomposite lenses were analogous to those of the commercial CVD wearables, and their water retention and wettability capabilities were superior to those in some of the commercially available contact lenses used for cosmetic/vision correction purposes. Hence, this work demonstrates the potential of gold nanocomposite lenses in CVD management and, more generally, color filtering applications.
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Journal articleAlQattan B, Doocey J, Ali M, et al., 2021,
Direct printing of nanostructured holograms on consumable substrates
, ACS Nano, Vol: 15, Pages: 2340-2349, ISSN: 1936-0851Direct texturing of nanostructures on consumable substrates and products is a challenge because of incompatible ingredients and materials’ properties. Here, we developed a direct laser-based method to print nanostructured holograms on dried films of consumable corn syrup solutions. A holographic laser (λ = 1050 nm) interference system was used to construct the nanostructures of the holograms on food for rainbow effects. The relationship between wavelength and periodicity contributed to the changing diffraction angle through the change of the refractive index (1.642). Increasing the sugar concentration (25–175 mg) in the syrup increased the diffraction efficiency of these holograms. The added amount of sugar in the composition increased the refractive index (7%) and decreased the light absorption (12.9%), which influenced the change of diffraction angle by 4.4°. The surface holograms displayed wideband visual diffraction of light extending from violet to red wavelengths. These holograms on edible materials can be imprinted onto commercial food products for adding aesthetic value and controlling perception.
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Journal articleSarabi MR, Jiang N, Ozturk E, et al., 2021,
Biomedical optical fibers
, LAB ON A CHIP, Vol: 21, Pages: 627-640, ISSN: 1473-0197
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