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Journal articleBilirgen AC, Toker M, Odabas S, et al., 2021,
Plant-Based Scaffolds in Tissue Engineering
, ACS BIOMATERIALS SCIENCE & ENGINEERING, Vol: 7, Pages: 926-938, ISSN: 2373-9878 -
Journal articleAlam F, Elsherif M, AiQattan B, et al., 2021,
3D printed contact lenses
, ACS Biomaterials Science and Engineering, Vol: 7, Pages: 794-803, ISSN: 2373-9878Although the manufacturing processes of contact lenses are well established, the use of additive manufacturing for their fabrication opens many new possibilities to explore. The current study demonstrates the fabrication of personalized smart contract lenses utilizing additive manufacturing. The study includes 3-dimensional (3D) modeling of contact lenses with the assistance of a computer aided designing tool based on standard commercial contact lens dimension, followed by the selection of the suitable materials and 3D printing of contact lenses. The 3D printing parameters were optimized to achieve the desired lens geometries, and a post processing treatment was performed to achieve a smooth surface finish. The study also presents functionalized contact lenses with built-in sensing abilities by utilizing microchannels at the contact lens edges. Tinted contact lenses were printed and nanopatterns were textured onto the contact lens surfaces through holographic laser ablation. 3D printed contact lenses have advantages over conventional contact lenses, offering customized ophthalmic devices and the capability to integrate with optical sensors for diagnostics.
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Journal articleJiang N, Davies S, Jiao Y, et al., 2021,
Doubly Photopolymerized Holographic Sensors
, ACS SENSORS, Vol: 6, Pages: 915-924, ISSN: 2379-3694 -
Journal articleDabbagh SR, Sarabi MR, Rahbarghazi R, et al., 2021,
3D-printed microneedles in biomedical applications
, ISCIENCE, Vol: 24 -
Journal articleDong X, Li H, Jiang Z, et al., 2021,
3D Deep Learning Enables Accurate Layer Mapping of 2D Materials
, ACS NANO, Vol: 15, Pages: 3139-3151, ISSN: 1936-0851 -
Journal articleLiu Q, Tian J, Tian Y, et al., 2021,
Near-Infrared-II Nanoparticles for Cancer Imaging of Immune Checkpoint Programmed Death-Ligand 1 and Photodynamic/Immune Therapy
, ACS NANO, Vol: 15, Pages: 515-525, ISSN: 1936-0851 -
Journal articleAtes HC, Yetisen AK, Guder F, et al., 2021,
Wearable devices for the detection of COVID-19
, NATURE ELECTRONICS, Vol: 4, Pages: 13-14, ISSN: 2520-1131 -
Journal articleDabbagh SR, Becher E, Ghaderinezhad F, et al., 2021,
Increasing the packing density of assays in paper-based microfluidic devices
, BIOMICROFLUIDICS, Vol: 15- Author Web Link
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- Citations: 10
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Journal articleElsherif M, Salih AE, Yetisen AK, et al., 2020,
Contact Lenses for Color Vision Deficiency
, ADVANCED MATERIALS TECHNOLOGIES, Vol: 6, ISSN: 2365-709X -
Journal articleChen Y, Zhang S, Cui Q, et al., 2020,
Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing
, LAB ON A CHIP, Vol: 20, Pages: 4205-4214, ISSN: 1473-0197 -
Journal articleMoreddu R, Elsherif M, Adams H, et al., 2020,
Integration of paper microfluidic sensors into contact lenses for tear fluid analysis
, LAB ON A CHIP, Vol: 20, Pages: 3970-3979, ISSN: 1473-0197 -
Journal articleDabbagh SR, Rabbi F, Dogan Z, et al., 2020,
Machine learning-enabled multiplexed microfluidic sensors
, BIOMICROFLUIDICS, Vol: 14- Author Web Link
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- Citations: 18
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Journal articleAkram MS, Pery N, Butler L, et al., 2020,
Challenges for biosimilars: focus on rheumatoid arthritis
, CRITICAL REVIEWS IN BIOTECHNOLOGY, Vol: 41, Pages: 121-153, ISSN: 0738-8551 -
Journal articleAlam F, Elsherif M, AlQattan B, et al., 2020,
Prospects for Additive Manufacturing in Contact Lens Devices
, ADVANCED ENGINEERING MATERIALS, Vol: 23, ISSN: 1438-1656 -
Journal articleJiang N, Yetisen AK, Linhart N, et al., 2020,
Fluorescent dermal tattoo biosensors for electrolyte analysis
, SENSORS AND ACTUATORS B-CHEMICAL, Vol: 320 -
Journal articleDong J, Yetisen AK, Dong X, et al., 2020,
Low-pass filtering compensation in common-path digital holographic microscopy
, APPLIED PHYSICS LETTERS, Vol: 117, ISSN: 0003-6951 -
Conference paperVasquez ESL, Yetisen AK, Vega K, 2020,
BraceIO
, UbiComp/ISWC '20: 2020 ACM International Joint Conference on Pervasive and Ubiquitous Computing and 2020 ACM International Symposium on Wearable Computers, Publisher: ACM -
Journal articleMoreddu R, Wolffsohn JS, Vigolo D, et al., 2020,
Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid
, SENSORS AND ACTUATORS B-CHEMICAL, Vol: 317 -
Journal articleAli M, Elsherif M, Salih AE, et al., 2020,
Surface modification and cytotoxicity of Mg-based bio-alloys: An overview of recent advances
, JOURNAL OF ALLOYS AND COMPOUNDS, Vol: 825, ISSN: 0925-8388 -
Journal articleHendi A, Hassan MU, Elsherif M, et al., 2020,
Healthcare applications of pH-sensitive hydrogels based devices: a review
, International Journal of Nanomedicine, Vol: 2020, Pages: 3887-3901, ISSN: 1176-9114pH-sensitive hydrogels have developed greatly over the past few years. This has been possible due to the synthesis of new hydrogel systems with increased sensitivity - the sensitivity of up to 10-5 pH units have already been established. Recently, pH-sensitive hydrogels have shown to be very useful for biomedical applications, such as targeted cancer treatment and treatment of skin lesions. Prolonged drug release has been made available through the use of such hydrogels. The synthesis of pH-sensitive hydrogels is also quick and cost-effective. This review presents a background on the properties of pH-sensitive hydrogels and discusses some of the hydrogels with different sensitivity ranges and their possible applications. A range of synthesis processes has also been briefly introduced along with the fabrication of different structures such as microcantilevers and contact lenses.
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Journal articleSalih AE, Elsherif M, Ali M, et al., 2020,
Ophthalmic Wearable Devices for Color Blindness Management
, ADVANCED MATERIALS TECHNOLOGIES, Vol: 5, ISSN: 2365-709X -
Journal articleDong X, Yetisen AK, Tian H, et al., 2020,
Line-Scan Hyperspectral Imaging Microscopy with Linear Unmixing for Automated Two-Dimensional Crystals Identification
, ACS PHOTONICS, Vol: 7, Pages: 1216-1225, ISSN: 2330-4022 -
Journal articleSharma N, Bergholt MS, Moreddu R, et al., 2020,
Clinician engineers – Re-injecting the thinking into medicine
, The Asia Pacific Scholar, Vol: 5, Pages: 48-50, ISSN: 2424-9335<jats:p>I. INTRODUCTIONMedicine historically relied on astute history and examination skills. As technology was lacking, ward rounds focused on debate and discussion of diagnoses and possible differential diagnoses based on the history and physical examination. The technology movement into healthcare was never truly predicted. With its occurrence, came the ability to scan a patient from top to toe via computed tomography and magnetic resonance imaging. Technology now serves as our main diagnostic tool (Patel, 2013).</jats:p>
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Journal articleDong X, Yetisen AK, Tian H, et al., 2020,
Analyses of hyperspectral imaging microscopy data sets of semiconducting 2D materials
, APPLIED PHYSICS EXPRESS, Vol: 13, ISSN: 1882-0778 -
Journal articleDong J, Wang S, Yetisen AK, et al., 2020,
Shear-unlimited common-path speckle interferometer
, OPTICS LETTERS, Vol: 45, Pages: 1305-1308, ISSN: 0146-9592 -
Journal articleYetisen AK, Jiang N, Castaneda Gonzalez CM, et al., 2020,
Scleral lens sensor for ocular electrolyte analysis
, Advanced Materials, Vol: 32, ISSN: 0935-9648The quantitative analysis of tear analytes in point-of-care settings can enable early diagnosis of ocular diseases. Here, a fluorescent scleral lens sensor is developed to quantitatively measure physiological levels of pH, Na+ , K+ , Ca2+ , Mg2+ , and Zn2+ ions. Benzenedicarboxylic acid, a pH probe, displays a sensitivity of 0.12 pH units within pH 7.0-8.0. Crown ether derivatives exhibit selectivity to Na+ and K+ ions within detection ranges of 0-100 and 0-50 mmol L-1 , and selectivities of 15.6 and 8.1 mmol L-1 , respectively. A 1,2 bis(o-aminophenoxy)ethane-N,N,-N',N'-tetraacetic-acid-based probe allows Ca2+ ion sensing with 0.02-0.05 mmol L-1 sensitivity within 0.50-1.25 mmol L-1 detection range. 5-Oxazolecarboxylic acid senses Mg2+ ions, exhibiting a sensitivity of 0.10-0.44 mmol L-1 within the range of 0.5-0.8 mmol L-1 . The N-(2-methoxyphenyl)iminodiacetate Zn2+ ion sensor has a sensitivity of 1 µmol L-1 within the range of 10-20 µmol L-1 . The fluorescent sensors are subsequently multiplexed in the concavities of an engraved scleral lens. A handheld ophthalmic readout device comprising light-emitting diodes (LEDs) and bandpass filters is fabricated to excite as well as read the scleral sensor. A smartphone camera application and an user interface are developed to deliver quantitative measurements with data deconvolution. The ophthalmic system enables the assessment of dry eye severity stages and the differentiation of its subtypes.
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Journal articleJiang N, Muck JE, Yetisen AK, 2020,
The Regulation of Wearable Medical Devices
, TRENDS IN BIOTECHNOLOGY, Vol: 38, Pages: 129-133, ISSN: 0167-7799- Author Web Link
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- Citations: 13
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Journal articleKurz W, Yetisen AK, Kaito MV, et al., 2020,
UV-Sensitive Wearable Devices for Colorimetric Monitoring of UV Exposure
, ADVANCED OPTICAL MATERIALS, Vol: 8, ISSN: 2195-1071 -
Journal articleSoussi S, Bergholt MS, Yetisen AK, et al., 2020,
Clinician engineers: The future of medical education
, Medical Teacher, Vol: 42, Pages: 478-478, ISSN: 0142-159X -
Journal articleRiaz RS, Elsherif M, Moreddu R, et al., 2019,
Anthocyanin-functionalized contact lens sensors for ocular pH monitoring
, ACS Omega, Vol: 4, Pages: 21792-21798, ISSN: 2470-1343Anthocyanins are bioactive compounds naturally found in a variety of leaves, fruits, and vegetables. Anthocyanin pigments undergo a modification in their chemical structure when exposed to different concentrations of hydrogen ions, and they were extensively studied to be used as active elements in biocompatible pH sensors. The ocular pH is a significant parameter to assess the ocular physiology in cases of postocular surgery, keratoconjunctivitis, and ocular rosacea. Contact lenses have the potential to be used as medical diagnostic devices for in situ continuous monitoring of the ocular physiology. Here, anthocyanin-functionalized contact lenses were developed as wearable sensors to monitor the ocular pH. Anthocyanin pigments were extracted from Brassica oleracea and used to functionalize the polymeric matrices of commercial soft contact lenses by soaking and drop-casting processes. Contact lenses responded to the physiological ocular pH of 6.5, 7.0, and 7.5, exhibiting a systematic color shift from pink (pH 6.5) to purple (pH 7.0) and blue (pH 7.5). The functionalization of contact lens sensors was evaluated as a function of the dye concentration. Quantitative values were obtained by comparing the RGB triplets of the colors obtained with the naturally extracted dye and with delphinidin chloride dye in 0.0 to 1.5 mmol L–1 aqueous solution. The functionalization of contact lenses was studied as a function of the soaking time, resulting in best results when soaking for 24 h. The dye leakage from the contact lenses in deionized water was evaluated, and a negligible leakage after 18 h was observed. Poly-2-hydroxy ethylmethacrylate contact lenses were fabricated and cross-linked with anthocyanin dye, resulting in a slight color shift upon pH changes from 6.5 to 7.4. Contact lens pH sensors may be used to continuously monitor the ocular pH at point-of-care settings.
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