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  • Journal article
    Sounderajah V, Ashrafian H, Aggarwal R, De Fauw J, Denniston AK, Greaves F, Karthikesalingam A, King D, Liu X, Markar SR, McInnes MDF, Panch T, Pearson-Stuttard J, Ting DSW, Golub RM, Moher D, Bossuyt PM, Darzi Aet al., 2020,

    Developing specific reporting guidelines for diagnostic accuracy studies assessing AI interventions: The STARD-AI Steering Group

    , Nature Medicine, Vol: 26, Pages: 807-808, ISSN: 1078-8956
  • Journal article
    Wheeler C, Furniss D, Galal-Edeen GH, Blandford A, Franklin BDet al., 2020,

    Patients' Perspectives on the Quality and Safety of Intravenous Infusions: A Qualitative Study

    , JOURNAL OF PATIENT EXPERIENCE, Vol: 7, Pages: 380-385, ISSN: 2374-3743
  • Journal article
    Ramdas K, Darzi A, Jain S, 2020,

    'Test, re-test, re-test': using inaccurate tests to greatly increase the accuracy of COVID-19 testing

    , Nature Methods, Vol: 26, Pages: 810-811, ISSN: 1548-7091
  • Journal article
    Archer S, Thibaut B, Dewa L, Ramtale S, D'Lima D, Simpson A, Murray K, Adam S, Darzi Aet al., 2020,

    Barriers and facilitators to incident reporting in mental healthcare settings: a qualitative study

    , Journal of Psychiatric and Mental Health Nursing, Vol: 27, Pages: 211-223, ISSN: 1351-0126

    IntroductionBarriers and facilitators to incident reporting have been widely researched in general healthcare. However, it is unclear if the findings are applicable to mental healthcare where care is increasingly complex.AimTo investigate if barriers and facilitators affecting incident reporting in mental healthcare are consistent with factors identified in other healthcare settings.MethodData were collected from focus groups (n=8) with 52 members of staff from across [a large Mental Health] Trust and analysed with thematic analysis.ResultsFive themes were identified during the analysis. Three themes (i)learning and improvement, (ii)time, and (iii)fear were consistent with the existing wider literature on barriers and facilitators to incident reporting. Two further themes (iv)interaction between patient diagnosis and incidents and (v)aftermath of an incident – prosecution specifically linked to the provision of mental healthcare.ConclusionsWhilst some barriers and facilitators to incident reporting identified in other settings are also prevalent in the mental healthcare setting, the increased incidence of violent and aggressive behaviour within mental healthcare presents a unique challenge for incident reporting.Clinical ImplicationsAlthough Interventions to improve incident reporting may be adapted/adopted from other settings, there is a need to develop specific interventions to improve reporting of violent and aggressive incidents.

  • Journal article
    Cresswell K, Sheikh A, Franklin BD, Krasuska M, Hung TN, Hinder S, Lane W, Mozaffar H, Mason K, Eason S, Potts HWW, Williams Ret al., 2020,

    Theoretical and methodological considerations in evaluating large-scale health information technology change programmes

    , BMC HEALTH SERVICES RESEARCH, Vol: 20
  • Journal article
    Kim JA, Wales D, Thompson A, Yang G-Zet al., 2020,

    Fiber-optic SERS probes fabricated using two-photon polymerization for rapid detection of bacteria

    , Advanced Optical Materials, Vol: 8, Pages: 1-12, ISSN: 2195-1071

    This study presents a novel fiber-optic surface-enhanced Raman spectroscopy (SERS) probe (SERS-on-a-tip) fabricated using a simple, two-step protocol based on off-the-shelf components and materials, with a high degree of controllability and repeatability. Two-photon polymerization and subsequent metallization was adopted to fabricate a range of SERS arrays on both planar substrates and end-facets of optical fibers. For the SERS-on-a-tip probes, a limit of detection of 10-7 M (Rhodamine 6G) and analytical enhancement factors of up to 1300 were obtained by optimizing the design, geometry and alignment of the SERS arrays on the tip of the optical fiber. Furthermore, strong repeatability and consistency were achieved for the fabricated SERS arrays, demonstrating that the technique may be suitable for large-scale fabrication procedures in the future. Finally, rapid SERS detection of live Escherichia coli cells was demonstrated using integration times in the milliseconds to seconds range. This result indicates strong potential for in vivo diagnostic use, particularly for detection of infections. Moreover, to the best of our knowledge, this represents the first report of detection of live, unlabeled bacteria using a fiber-optic SERS probe.

  • Journal article
    Aufegger L, Serou N, Chen S, Franklin BDet al., 2020,

    Evaluating users' experiences of electronic prescribing systems in relation to patient safety: a mixed methods study

    , BMC Medical Informatics and Decision Making, Vol: 20, ISSN: 1472-6947

    BackgroundUser interface (UI) design features such as screen layout, density of information, and use of colour may affect the usability of electronic prescribing (EP) systems, with usability problems previously associated with medication errors. To identify how to improve existing systems, our aim was to explore prescribers’ perspectives of UI features of a commercially available EP system, and how these may affect patient safety.MethodsTwo studies were conducted, each including ten participants prescribing a penicillin for a test patient with a penicillin allergy. In study 1, eye-gaze tracking was used as a means to explore visual attention and behaviour during prescribing, followed by a self-reported EP system usability scale. In study 2, a think-aloud method and semi-structured interview were applied to explore participants’ thoughts and views on prescribing, with a focus on UI design and patient safety.ResultsStudy 1 showed high visual attention toward information on allergies and patient information, allergy pop-up alerts, and medication order review and confirmation, with less visual attention on adding medication. The system’s usability was rated ‘below average’. In study 2, participants highlighted EP design features and workflow, including screen layout and information overload as being important for patient safety, benefits of EP systems such as keeping a record of relevant information, and suggestions for improvement in relation to system design (colour, fonts, customization) and patient interaction.ConclusionsSpecific UI design factors were identified that may improve the usability and/or safety of EP systems. It is suggested that eye-gaze tracking and think-aloud methods are used in future experimental research in this area. Limitations include the small sample size; further work should include similar studies on other EP systems.

  • Journal article
    Franklin BD, Abel G, Shojania KG, 2020,

    Medication non-adherence: an overlooked target for quality improvement interventions

    , BMJ QUALITY & SAFETY, Vol: 29, Pages: 271-273, ISSN: 2044-5415
  • Journal article
    Posthuma LM, Downey C, Visscher MJ, Ghazali DA, Joshi M, Ashrafian H, Khan S, Darzi A, Goldstone J, Preckel Bet al., 2020,

    Remote wireless vital signs monitoring on the ward for early detection of deteriorating patients: A case series

    , INTERNATIONAL JOURNAL OF NURSING STUDIES, Vol: 104, ISSN: 0020-7489
  • Journal article
    Zhao M, Oude Vrielink TJC, Kogkas A, Runciman M, Elson D, Mylonas Get al., 2020,

    LaryngoTORS: a novel cable-driven parallel robotic system for transoral laser phonosurgery

    , IEEE Robotics and Automation Letters, Vol: 5, Pages: 1516-1523, ISSN: 2377-3766

    Transoral laser phonosurgery is a commonly used surgical procedure in which a laser beam is used to perform incision, ablation or photocoagulation of laryngeal tissues. Two techniques are commonly practiced: free beam and fiber delivery. For free beam delivery, a laser scanner is integrated into a surgical microscope to provide an accurate laser scanning pattern. This approach can only be used under direct line of sight, which may cause increased postoperative pain to the patient and injury, is uncomfortable for the surgeon during prolonged operations, the manipulability is poor and extensive training is required. In contrast, in the fiber delivery technique, a flexible fiber is used to transmit the laser beam and therefore does not require direct line of sight. However, this can only achieve manual level accuracy, repeatability and velocity, and does not allow for pattern scanning. Robotic systems have been developed to overcome the limitations of both techniques. However, these systems offer limited workspace and degrees-of-freedom (DoF), limiting their clinical applicability. This work presents the LaryngoTORS, a robotic system that aims at overcoming the limitations of the two techniques, by using a cable-driven parallel mechanism (CDPM) attached at the end of a curved laryngeal blade for controlling the end tip of the laser fiber. The system allows autonomous generation of scanning patterns or user driven freepath scanning. Path scan validation demonstrated errors as low as 0.054±0.028 mm and high repeatability of 0.027±0.020 mm (6×2 mm arc line). Ex vivo tests on chicken tissue have been carried out. The results show the ability of the system to overcome limitations of current methods with high accuracy and repeatability using the superior fiber delivery approach.

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