@article{Liu:2015:10.1371/journal.pone.0137802,
author = {Liu, M and Lam, MK-H and Zhang, Q and Elderfield, R and Barclay, WS and Shaw, P-C},
doi = {10.1371/journal.pone.0137802},
journal = {PLOS One},
title = {The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein},
url = {http://dx.doi.org/10.1371/journal.pone.0137802},
volume = {10},
year = {2015}
}

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TY  - JOUR
AB  - Influenza nucleoprotein (NP) is a major component of the ribonucleoprotein (vRNP) in influenzavirus, which functions for the transcription and replication of viral genome. Comparedto the nucleoprotein of influenza A (ANP), the N-terminal region of influenza B nucleoprotein(BNP) is much extended. By virus reconstitution, we found that the first 38 residues areessential for viral growth. We further illustrated the function of BNP by mini-genome reconstitution,fluorescence microscopy, electron microscopy, light scattering and gel shift.Results show that the N terminus is involved in the formation of both higher homo-oligomersof BNP and BNP-RNA complex.
AU  - Liu,M
AU  - Lam,MK-H
AU  - Zhang,Q
AU  - Elderfield,R
AU  - Barclay,WS
AU  - Shaw,P-C
DO  - 10.1371/journal.pone.0137802
PY  - 2015///
SN  - 1932-6203
TI  - The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein
T2  - PLOS One
UR  - http://dx.doi.org/10.1371/journal.pone.0137802
UR  - http://hdl.handle.net/10044/1/28661
VL  - 10
ER  - 

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