@article{Koutsoudakis:2017:10.1128/AAC.02354-16,
author = {Koutsoudakis, G and Paris, de Leon A and Herrera, C and Dorner, M and Perez-Vilaro, G and Lyonnais, S and Grijalvo, S and Eritja, R and Meyerhans, A and Mirambeau, G and Diez, J},
doi = {10.1128/AAC.02354-16},
journal = {ANTIMICROBIAL AGENTS AND CHEMOTHERAPY},
title = {Oligonucleotide-Lipid Conjugates Forming G-Quadruplex Structures Are Potent and Pangenotypic Hepatitis C Virus Entry Inhibitors In Vitro and Ex Vivo},
url = {http://dx.doi.org/10.1128/AAC.02354-16},
volume = {61},
year = {2017}
}

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TY  - JOUR
AB  - A hepatitis C virus (HCV) epidemic affecting HIV-infected men who have sex with men (MSM) is expanding worldwide. In spite of the improved cure rates obtained with the new direct-acting antiviral drug (DAA) combinations, the high rate of reinfection within this population calls urgently for novel preventive interventions. In this study, we determined in cell culture and ex vivo experiments with human colorectal tissue that lipoquads, G-quadruplex DNA structures fused to cholesterol, are efficient HCV pangenotypic entry and cell-to-cell transmission inhibitors. Thus, lipoquads may be promising candidates for the development of rectally applied gels to prevent HCV transmission.
AU  - Koutsoudakis,G
AU  - Paris,de Leon A
AU  - Herrera,C
AU  - Dorner,M
AU  - Perez-Vilaro,G
AU  - Lyonnais,S
AU  - Grijalvo,S
AU  - Eritja,R
AU  - Meyerhans,A
AU  - Mirambeau,G
AU  - Diez,J
DO  - 10.1128/AAC.02354-16
PY  - 2017///
SN  - 0066-4804
TI  - Oligonucleotide-Lipid Conjugates Forming G-Quadruplex Structures Are Potent and Pangenotypic Hepatitis C Virus Entry Inhibitors In Vitro and Ex Vivo
T2  - ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
UR  - http://dx.doi.org/10.1128/AAC.02354-16
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403532100043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/48707
VL  - 61
ER  - 

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