Metabolic Medicine

Two people in a lab

The section of metabolic medicine undertakes clinical translational research focussing on type 1 diabetes. We co-ordinate the ADDRESS2 study of new-onset type 1 diabetes which is now one of the largest cohorts of adults studied from diagnosis. The ADDRESS2 study has led to new insights into the pathophysiology of type 1 diabetes and work to establish the impact of viruses in the development of type 1 diabetes is ongoing. Active areas of investigation include how both new and existing technologies are applied to type 1 diabetes, with a focus on interventions to prevent hypoglycaemia, and the development and assessment of artificial intelligence strategies to support people living with type 1 diabetes.

We work closely with biomedical engineers to develop new technologies and solutions to support type 1 diabetes self-management including novel glucose sensing modalities, decision support using smartphones, and integration of wearable technologies.

Other research areas include diabetes diagnostic stratification, gestational diabetes and type 2 diabetes prevention, and work to establish key differences between diabetes sub-types across different ethnicities.

Key studies, research groups and collaborations

ADDRESS-2 study - learning about the characteristics of people newly diagnosed with type 1 with diabetes in the UK and supporting other research into type 1 diabetes.
ABC4D study - Advanced Bolus Calculator for Diabetes.
AIR-CGM - Assessment of the Impact of Real-Time Continuous Glucose Monitoring on People Presenting With Severe Hypoglycaemia.
ALPHA - Assessment of the Accuracy of Continuous Glucose Sensors in People With Diabetes Undergoing Haemodialysis.
ARISES – Adaptive, Real-time, Intelligent System to Enhance Self-care of chronic disease.
BiAP study - Clinical Evaluation of an Artificial Pancreas in people with Type 1 Diabetes. Publication found here.
I HART CGM study - Comparison of Continuous Glucose Monitoring vs. Flash Glucose Monitoring in Type 1 diabetes. Publication found here.
PACE – The impact of predictive hypoglycaemia alert function in physical activity for people with T1DM.
PEPPER study - Personalised Decision Support system for diabetes management in Type 1 Diabetes.
MY DIABETES study - Characterising Young-Onset Diabetes in two UK ethnic groups, specifically identifying potential genetic causes to their diabetes known as Maturity Onset Diabetes of the Young (MODY).
WynnMet - The Wynn Database: Metabolic Risk Factors and Mortality

Collaborations

Section leadership

Head of Metabolic Medicine - Dr Shivani Misra

Dr Shivani Misra is a Wellcome Trust Clinical Career Development Fellow & a Senior Clinical Lecturer within Imperial College London & Honorary Diabetes Consultant. Dr Misra has two main areas of research interest and clinical expertise: 1) She leads a portfolio of studies that investigate the genetics, epidemiology, classification and treatment of early-onset type 2 diabetes, defined as a diagnosis of type 2 diabetes in childhood or early-adulthood. 2) She investigates type 2 diabetes heterogeneity & precision medicine efforts in type 2 diabetes focussing on population diversity & health equity

Further information on Dr Shivani Misra