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• Book chapter
  Liu Y, Childs RA, Feizi T, 2014,

  Neoglycolipid (NGL)-Based Glycan Microarray System for Ligand Discovery

  , Glycoscience: Biology and Medicine, Editors: Endo, Seeberger, Hart, Wong, Taniguchi, Publisher: Springer Japan, ISBN: 978-4-431-54836-2

  It is now appreciated that carbohydrate–protein interactions are integral to many physiological processes and are directly or indirectly involved in the majority of disease processes, infective or noninfective, including cancer. Carbohydrate microarrays have emerged as powerful tools for elucidating the ligands involved in these interactions. However, as oligosaccharides cannot be cloned and expressed as with DNA and proteins, few laboratories have libraries of sequence-defined oligosaccharide probes with sufficient breadth to tackle the unraveling of diverse carbohydrate–protein interactions. Microarray screening analyses are offered to the scientific community by the Wellcome Trust-supported carbohydrate microarray facility in the Glycosciences Laboratory at Imperial College London and by the NIH-supported Consortium for Functional Glycomics. This chapter gives a brief account of a technology, the neoglycolipid (NGL) technology, first introduced in 1985 and converted into a glycan microarray system in 2002. Results are highlighted from analyses using this system, also including designer arrays, which entail microarrays of NGLs specifically derived from relevant ligand-bearing glycomes in order to reveal the oligosaccharide ligands they harbor and lead to their isolation and characterization. These include discoveries of new ligands in endogenous recognition and pathogen–host interactions and assignments of long-sought cancer-associated antigens.

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• Journal article
  Kanagawa M, Liu Y, Hanashima S, Ikeda A, Chai W, Nakano Y, Kojima-Aikawa K, Feizi T, Yamaguchi Yet al., 2014,

  Structural Basis for Multiple Sugar Recognition of Jacalin-related Human ZG16p Lectin

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 289, Pages: 16954-16965
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  • Citations: 26
• Journal article
  Gao C, Liu Y, Zhang H, Zhang Y, Fukuda MN, Palma AS, Kozak RP, Childs RA, Nonaka M, Li Z, Siegel DL, Hanfland P, Peehl DM, Chai W, Greene MI, Ten Fet al., 2014,

  Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 289, Pages: 16462-16477, ISSN: 0021-9258
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  • Citations: 36
• Journal article
  Nonaka M, Fukuda MN, Gao C, Li Z, Zhang H, Greene MI, Peehl DM, Ten F, Fukuda Met al., 2014,

  Determination of Carbohydrate Structure Recognized by Prostate-specific F77 Monoclonal Antibody through Expression Analysis of Glycosyltransferase Genes

  , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 289, Pages: 16478-16486
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  • Citations: 23
• Journal article
  Khan ZM, Liu Y, Neu U, Gilbert M, Ehlers B, Feizi T, Stehle Tet al., 2014,

  Crystallographic and Glycan Microarray Analysis of Human Polyomavirus 9 VP1 Identifies N-Glycolyl Neuraminic Acid as a Receptor Candidate

  , JOURNAL OF VIROLOGY, Vol: 88, Pages: 6100-6111, ISSN: 0022-538X
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  • Citations: 28
• Journal article
  Falkowska E, Le KM, Ramos A, Doores KJ, Lee JH, Blattner C, Ramirez A, Derking R, van Gils MJ, Liang C-H, Mcbride R, von Bredow B, Shivatare SS, Wu C-Y, Chan-Hui P-Y, Liu Y, Feizi T, Zwick MB, Koff WC, Seaman MS, Swiderek K, Moore JP, Evans D, Paulson JC, Wong C-H, Ward AB, Wilson IA, Sanders RW, Poignard P, Burton DRet al., 2014,

  Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers

  , IMMUNITY, Vol: 40, Pages: 657-668, ISSN: 1074-7613
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  • Citations: 268
• Journal article
  York WS, Agravat S, Aoki-Kinoshita KF, McBride R, Campbell MP, Costello CE, Dell A, Feizi T, Haslam SM, Karlsson N, Khoo K-H, Kolarich D, Liu Y, Novotny M, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Struwe WB, Tiemeyer M, Wells L, Zaia J, Kettner Cet al., 2014,

  MIRAGE: The minimum information required for a glycomics experiment

  , GLYCOBIOLOGY, Vol: 24, Pages: 402-406, ISSN: 0959-6658
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  • Citations: 80
• Journal article
  Palma AS, Feizi T, Childs RA, Chai W, Liu Yet al., 2014,

  The neoglycolipid (NGL)-based oligosaccharide microarray system poised to decipher the meta-glycome

  , CURRENT OPINION IN CHEMICAL BIOLOGY, Vol: 18, Pages: 87-94, ISSN: 1367-5931
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  • Citations: 66
• Journal article
  Crusat M, Liu J, Palma AS, Childs RA, Liu Y, Wharton SA, Lin YP, Coombs PJ, Martin SR, Matrosovich M, Chen Z, Stevens DJ, Vo MH, Tran TT, Le NTN, Lam AN, Do QH, van Doorn HR, Tran TH, Conradt HS, Kiso M, Gamblin SJ, Chai W, Skehel JJ, Hay AJ, Farrar J, de Jong MD, Feizi Tet al., 2013,

  Changes in the hemagglutinin of H5N1 viruses during human infection - Influence on receptor binding

  , VIROLOGY, Vol: 447, Pages: 326-337, ISSN: 0042-6822
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  • Citations: 27
• Conference paper
  Palma AS, Pinheiro B, Liu Y, Takeda Y, Chai W, Ito Y, Romao MJ, Carvalho AL, Feizi Tet al., 2013,

  The Structural Basis of the Recognition of Di-glucosylated N-glycans by the ER Lectin Malectin

  , Annual Conference of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1368-1369, ISSN: 0959-6658
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